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interferon alpha and beta receptor subunit 1

Summary

Gene Symbol

IFNAR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3454

PubChem

3454

Alliance of Genome Resources

HGNC:5432

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disease variant
Disulfide bond
Endosome
Glycoprotein
Isopeptide bond
Lysosome
Palmitate
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P17181	Cytokine receptor class-II member 1 Cytokine receptor family 2 member 1 Type I interferon receptor 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
receptor signaling pathway via JAK-STAT	IDA	7526154 7657660 7813427 8605876
regulation of receptor signaling pathway via JAK-STAT	IEA
type I interferon-mediated signaling pathway	IBA IDA NAS	21854986 30936491 7665574
positive regulation of cellular respiration	IMP	25930096
cellular response to interferon-alpha	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

interferon-mediated signaling pathway [inference]

type I interferon-mediated signaling pathway

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

cellular response to virus

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to virus

cellular response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to virus

cellular response to virus

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide

response to cytokine [inference]

response to interferon-alpha [inference]

cellular response to interferon-alpha

response to interferon-beta [inference]

cellular response to interferon-beta

cellular response to cytokine stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

response to oxygen-containing compound [inference]

response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of generation of precursor metabolites and energy [inference]

regulation of cellular respiration [inference]

positive regulation of cellular respiration

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

interferon-mediated signaling pathway [inference]

type I interferon-mediated signaling pathway

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of generation of precursor metabolites and energy [inference]

regulation of cellular respiration [inference]

positive regulation of cellular respiration

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA IDA IMP TAS	14532120 35442418
lysosome	IEA
late endosome	IEA
receptor complex	IPI	21854986

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
JAK pathway signal transduction adaptor activity	IDA TAS	34813358 8605876
cytokine binding	IPI	7813427
type I interferon binding	ISS
protein binding	IPI	12220192 14532120 24704786 32296183 33961781 7665574 8605876 9121453 9677371
type I interferon receptor activity	IBA IDA IMP	21854986 31270247 33252644 35442418 7665574 7813427

GO Hierarchy

interferon binding [inference]

type I interferon binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

interferon receptor activity [inference]

type I interferon receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

interferon receptor activity [inference]

type I interferon receptor activity

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

JAK pathway signal transduction adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1883	hepatitis C	Alliance of Genome Resources
DOID:612	primary immunodeficiency disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 52 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	3454	Xenbase:XB-GENE-17335504
Danio rerio	3588	ZFIN:ZDB-GENE-050909-1
Mus musculus	15975	RGD:1305399	MOUSE17665
Danio rerio	16155	ZFIN:ZDB-GENE-050909-1
Bos taurus	282257		BOVIN14173
Rattus norvegicus	288264		RATNO04376
Sus scrofa	396658		PIGXX06070
Ovis aries	443126		SHEEP01171
Canis lupus familiaris	609830		CANLF12821
Equus caballus	100063402		HORSE24621