GlyCosmos Portal

Submissions

interferon alpha and beta receptor subunit 1

Summary

Gene Symbol

IFNAR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3454

PubChem

3454

Alliance of Genome Resources

HGNC:5432

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disease variant
Disulfide bond
Endosome
Glycoprotein
Isopeptide bond
Lysosome
Palmitate
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P17181	Cytokine receptor class-II member 1 Cytokine receptor family 2 member 1 Type I interferon receptor 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
receptor signaling pathway via JAK-STAT	IDA	7526154 7657660 7813427 8605876
response to virus	TAS	2153461
response to lipopolysaccharide	ISS
cellular response to interferon-alpha	ISS
cellular response to interferon-beta	IDA	7813427

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

interferon-mediated signaling pathway [inference]

type I interferon-mediated signaling pathway

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

cellular response to virus

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to virus

cellular response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to virus

cellular response to virus

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide

response to cytokine [inference]

response to interferon-alpha [inference]

cellular response to interferon-alpha

response to interferon-beta [inference]

cellular response to interferon-beta

cellular response to cytokine stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

response to oxygen-containing compound [inference]

response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of generation of precursor metabolites and energy [inference]

regulation of cellular respiration [inference]

positive regulation of cellular respiration

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

interferon-mediated signaling pathway [inference]

type I interferon-mediated signaling pathway

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of generation of precursor metabolites and energy [inference]

regulation of cellular respiration [inference]

positive regulation of cellular respiration

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
lysosome	IEA
late endosome	IEA
plasma membrane	TAS
plasma membrane	IDA	14532120
plasma membrane	IMP	35442418

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
type I interferon receptor activity	IDA	21854986 7665574 7813427
type I interferon receptor activity	IMP	31270247 33252644 35442418
type I interferon receptor activity	IBA
protein binding	IPI	12220192 14532120 24704786 32296183 33961781 7665574 8605876 9121453 9677371
JAK pathway signal transduction adaptor activity	TAS	34813358

GO Hierarchy

interferon binding [inference]

type I interferon binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

interferon receptor activity [inference]

type I interferon receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

interferon receptor activity [inference]

type I interferon receptor activity

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

JAK pathway signal transduction adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Interferon alpha/beta receptor 1

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
type I interferon receptor activity

Displaying **all 4** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Interferon/interleukin receptor domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1883	hepatitis C	Alliance of Genome Resources
DOID:612	primary immunodeficiency disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 52 in total

1

2

3

4

5

6

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	3454	Xenbase:XB-GENE-17335504
Danio rerio	3588	ZFIN:ZDB-GENE-050909-1
Mus musculus	15975	RGD:1305399	MOUSE17665
Danio rerio	16155	ZFIN:ZDB-GENE-050909-1
Bos taurus	282257		BOVIN14173
Rattus norvegicus	288264		RATNO04376
Sus scrofa	396658		PIGXX06070
Ovis aries	443126		SHEEP01171
Canis lupus familiaris	609830		CANLF12821
Equus caballus	100063402		HORSE24621

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements