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interferon alpha and beta receptor subunit 1

Summary

Gene Symbol

IFNAR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3454

PubChem

3454

Alliance of Genome Resources

HGNC:5432

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disease variant
Disulfide bond
Endosome
Glycoprotein
Isopeptide bond
Lysosome
Palmitate
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P17181	Cytokine receptor class-II member 1 Cytokine receptor family 2 member 1 Type I interferon receptor 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
receptor signaling pathway via JAK-STAT	IDA	7526154 7657660 7813427 8605876
response to virus	TAS	2153461
response to lipopolysaccharide	ISS
cellular response to interferon-alpha	ISS
cellular response to interferon-beta	IDA	7813427

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

interferon-mediated signaling pathway [inference]

type I interferon-mediated signaling pathway

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

cellular response to virus

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to virus

cellular response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to virus

cellular response to virus

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide

response to cytokine [inference]

response to interferon-alpha [inference]

cellular response to interferon-alpha

response to interferon-beta [inference]

cellular response to interferon-beta

cellular response to cytokine stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

response to oxygen-containing compound [inference]

response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of generation of precursor metabolites and energy [inference]

regulation of cellular respiration [inference]

positive regulation of cellular respiration

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

interferon-mediated signaling pathway [inference]

type I interferon-mediated signaling pathway

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of generation of precursor metabolites and energy [inference]

regulation of cellular respiration [inference]

positive regulation of cellular respiration

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
plasma membrane	IBA
receptor complex	IPI	21854986

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
JAK pathway signal transduction adaptor activity	IDA	8605876
cytokine binding	IPI	7813427
type I interferon binding	ISS

GO Hierarchy

interferon binding [inference]

type I interferon binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

interferon receptor activity [inference]

type I interferon receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

interferon receptor activity [inference]

type I interferon receptor activity

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

JAK pathway signal transduction adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Interferon alpha/beta receptor 1

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
type I interferon receptor activity

Displaying **all 4** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Interferon/interleukin receptor domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1883	hepatitis C	Alliance of Genome Resources
DOID:612	primary immunodeficiency disease	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 52 in total

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Species	Gene ID	Orthologous MAtrix
Pelodiscus sinensis	102462024	PELSI14994
Vicugna pacos	102530410	VICPA02076
Chlorocebus sabaeus	103216875	CHLSB07992
Carlito syrichta	103269359	CARSF21312
Anolis carolinensis	103281135	ANOCA12261
Serinus canaria	103824810	SERCA22471
Pteropus vampyrus	105295861	PTEVA05004
Mandrillus leucophaeus	105553144	MANLE24700
Propithecus coquereli	105820771	PROCO13764
Crocodylus porosus	109305776	CROPO03404

GlyTouCan

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Annotation

OrthoDB (Group)

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Acknowledgements