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Angiotensin converting enzyme

Summary

Gene Symbol

Ance

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

34805

PubChem

34805

Alliance of Genome Resources

FB:FBgn0012037

Annotation

Keyword

3D-structure
Carboxypeptidase
Coiled coil
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Secreted
Signal
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q10714	Dipeptidyl carboxypeptidase I Kininase II
X2J8C3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
sexual reproduction	IEP	17921161
proteolysis	IDA IEA	12431739 12431741 16403023 17921161 23082758 7775412 8761461 9461491 9839949
response to symbiotic bacterium	IEP	18171476
metamorphosis	IEP	12093364
peptide hormone processing	IDA	12431739 9461491 9839949

GO Hierarchy

biological process

reproduction [inference]

sexual reproduction

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

hormone metabolic process [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

multicellular organismal process [inference]

multicellular organism development [inference]

metamorphosis

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

metamorphosis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA
plasma membrane	IBA
extracellular space	IBA IDA	12431741 17921161 7775412 9839949

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
peptidyl-dipeptidase activity	IDA IEA	10913309 12431739 12431741 16403023 17921161 23082758 7775412 8761461 9461491 9839949
metal ion binding
metallopeptidase activity	IBA IDA IEA	12633854
carboxypeptidase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity

exopeptidase activity [inference]

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity

exopeptidase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

angiotensin-converting enzyme

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
carboxypeptidase activity
hydrolase activity
metal ion binding
metallopeptidase activity
peptidyl-dipeptidase activity
positive regulation of systemic arterial blood pressure
proteolysis
regulation of systemic arterial blood pressure by renin-angiotensin

Displaying 1 entry
InterPro
Peptidase M2, peptidyl-dipeptidase A

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
extracellular space	PMID:12431741 PMID:17921161 PMID:7775412 PMID:9839949
membrane	FB:FBrf0231198

Disease

Disease Ontology

Displaying entries **41 - 50** of 81 in total

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DO ID	Disease Name	Source
DOID:2986	IgA glomerulonephritis	Alliance of Genome Resources
DOID:2987	familial mediterranean fever	Alliance of Genome Resources
DOID:3021	acute kidney failure	Alliance of Genome Resources
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:3500	gallbladder adenocarcinoma	Alliance of Genome Resources
DOID:3525	middle cerebral artery infarction	Alliance of Genome Resources
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:3587	pancreatic ductal carcinoma	Alliance of Genome Resources
DOID:3770	pulmonary fibrosis	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 57** of 57 in total

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Species	Gene ID	OrthoDB
Drosophila subobscura	117901190	7241_1:002aaf
Drosophila subpulchrella	119546766	1486046_1:00097b
Drosophila subpulchrella	119546767	1486046_0:00165e
Drosophila santomea	120444153	129105_1:0000a0
Drosophila ficusphila	122320657	30025_1:0027aa
Drosophila teissieri	122615798	7243_1:000232
Drosophila gunungcola	128262134	103775_0:001138

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Annotation

OrthoDB (Group)

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Acknowledgements