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interleukin 1 receptor antagonist

Summary

Gene Symbol

IL1RN

Organism

Homo sapiens (human)

External Links

NCBI Gene

3557

PubChem

3557

Alliance of Genome Resources

HGNC:6000

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Direct protein sequencing
Disulfide bond
Glycoprotein
Pharmaceutical
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P18510	ICIL-1RA IL1 inhibitor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
negative regulation of cytokine-mediated signaling pathway	IEA
inflammatory response to antigenic stimulus
lipid metabolic process	IEA
acute-phase response	IDA	9185517
inflammatory response	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response

inflammatory response to antigenic stimulus

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process

cellular process [inference]

signal transduction

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

inflammatory response to antigenic stimulus

acute inflammatory response [inference]

acute-phase response

immune response

inflammatory response to antigenic stimulus

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

regulation of heterotypic cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

regulation of cell-cell adhesion involved in gastrulation [inference]

negative regulation of heterotypic cell-cell adhesion

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

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GO Term	Evidence Code	PMID
extracellular space	IDA	10443688 12483741 2137200 9185517
extracellular space	IBA
nucleoplasm	IDA
centrosome	IDA
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cytosol

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
interleukin-1 receptor antagonist activity	IDA	2137200 2139180
interleukin-1 receptor antagonist activity	IBA
protein binding	IPI	21044950 33961781 9062194
interleukin-1 type I receptor antagonist activity	IDA	1828071
interleukin-1 type II receptor antagonist activity	IDA	1830582

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

interleukin-1 receptor binding

interleukin-1 receptor antagonist activity

receptor ligand activity [inference]

cytokine activity

receptor antagonist activity [inference]

interleukin-1 receptor antagonist activity

growth factor receptor binding [inference]

interleukin-1 receptor binding

growth factor binding [inference]

interleukin-1 binding [inference]

interleukin-1 receptor antagonist activity

cytokine binding [inference]

interleukin-1 binding [inference]

interleukin-1 receptor antagonist activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

signaling receptor inhibitor activity [inference]

receptor antagonist activity [inference]

interleukin-1 receptor antagonist activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity [inference]

receptor antagonist activity [inference]

interleukin-1 receptor antagonist activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

interleukin-1 receptor antagonist protein

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
cytokine activity
immune response
inflammatory response to antigenic stimulus
inflammatory response
interleukin-1 receptor antagonist activity
interleukin-1 receptor binding
negative regulation of interleukin-1-mediated signaling pathway

Displaying **all 3** entries
InterPro
Cytokine IL1/FGF
Interleukin-1 family
Interleukin-1 receptor antagonist/Interleukin-36

Disease

Disease Ontology

Displaying entries **1 - 10** of 64 in total

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DO ID	Disease Name	Source
DOID:0050589	inflammatory bowel disease	Alliance of Genome Resources
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:0050854	Muckle-Wells syndrome	Alliance of Genome Resources
DOID:0060645	chronic recurrent multifocal osteomyelitis	Alliance of Genome Resources
DOID:0080158	herpes simplex virus keratitis	Alliance of Genome Resources
DOID:0080652	calcium oxalate nephrolithiasis	Alliance of Genome Resources
DOID:0080998	acute necrotizing pancreatitis	Alliance of Genome Resources
DOID:0081120	Graves ophthalmopathy	Alliance of Genome Resources
DOID:0081267	graft-versus-host disease	Alliance of Genome Resources
DOID:10126	keratoconus	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 47 in total

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Species	Gene ID	Orthologous MAtrix
Ursus maritimus	103671490	URSMA00559
Nannospalax galili	103750880	NANGA24914
Rhinopithecus roxellana	104664524	RHIRO41967
Macaca nemestrina	105471778	MACNE29924
Mandrillus leucophaeus	105530443	MANLE36668
Cercocebus atys	105591115	CERAT34622
Aotus nancymaae	105707897	AOTNA40905
Propithecus coquereli	105820330	PROCO28259
Dipodomys ordii	106001191	DIPOR23508
Rhinopithecus bieti	108541817	RHIBE36257

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OrthoDB (Group)

International Collaboration

Acknowledgements