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interleukin 2 receptor subunit beta

Summary

Gene Symbol

IL2RB

Organism

Homo sapiens (human)

External Links

NCBI Gene

3560

PubChem

3560

Alliance of Genome Resources

HGNC:6009

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
Disulfide bond
Glycoprotein
Host-virus interaction
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P14784	High affinity IL-2 receptor subunit beta Interleukin-15 receptor subunit beta p70-75

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein-containing complex assembly	TAS	2467293
positive regulation of phagocytosis	IMP	15123770
interleukin-15-mediated signaling pathway	IMP	15123770 31040184
negative regulation of apoptotic process	IDA	7736574
cytokine-mediated signaling pathway	IBA IDA	7736574

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

response to stimulus [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
interleukin-2 receptor complex	TAS	2467293
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

interleukin-2 receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

interleukin-2 receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
interleukin-2 binding	IBA IMP ISS	2467293 31040184 31040185
protein binding	IPI	16477002 22446627 23104097 25416956 32296183
cytokine receptor activity	IBA
coreceptor activity	IDA	7973659 8026467
interleukin-15 receptor activity	IDA	15123770

GO Hierarchy

molecular function

binding [inference]

protein binding

growth factor binding [inference]

interleukin-2 binding

cytokine binding [inference]

interleukin-2 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

coreceptor activity

immune receptor activity [inference]

cytokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

interleukin-2 receptor subunit beta

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cytokine-mediated signaling pathway
interleukin-2 binding

Displaying **all 5** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Interleukin-2 receptor subunit beta, N-terminal
Short hematopoietin receptor, family 1, conserved site

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0111997	immunodeficiency 63	Alliance of Genome Resources
DOID:2043	hepatitis B	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:437	myasthenia gravis	Alliance of Genome Resources
DOID:9146	visceral leishmaniasis	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 59 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Ovis aries	101107088		SHEEP14741
Gorilla gorilla gorilla	101139583	9595_0:0055e0	GORGO24099
Taeniopygia guttata	101232975		TAEGU09218
Tursiops truncatus	101330858		TURTR07448
Jaculus jaculus	101602353		JACJA01372
Mustela putorius furo	101674646		MUSPF17392
Heterocephalus glaber	101726369		HETGA18005
Anas platyrhynchos platyrhynchos	101791719		ANAPP03819
Ficedula albicollis	101809303		FICAL00549
Chrysemys picta bellii	101932173		CHRPI06542

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements