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Glycomics MS Repository for glycan annotations from GlycoWorkbench
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Repository for lectin-assisted multimodality data
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Guidelines
MIRAGE
interleukin 6
Summary
- Gene Symbol
-
- IL6
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acute phase
- Cytokine
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Growth factor
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Secreted
- Signal
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| neutrophil apoptotic process | ||
| germinal center B cell differentiation | ||
| hepatic immune response | ||
| hepatic immune response | ||
| neutrophil mediated immunity |
GO Hierarchy
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of epithelial to mesenchymal transition
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of translation
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-21 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of epithelial to mesenchymal transition
biological process
immune system process [inference]
cellular process [inference]
multicellular organismal process [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of production of molecular mediator of immune response [inference]
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of production of molecular mediator of immune response [inference]
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of production of molecular mediator of immune response [inference]
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of response to stimulus [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of production of molecular mediator of immune response [inference]
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| extracellular space | ||
| endoplasmic reticulum lumen | ||
| interleukin-6 receptor complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytokine activity | ||
| cytokine activity | ||
| cytokine activity | ||
| cytokine activity | ||
| cytokine activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- interleukin-6
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| T-helper 17 cell lineage commitment |
| acute-phase response |
| cytokine activity |
| growth factor activity |
| immune response |
| interleukin-6 receptor binding |
| InterPro |
|---|
| Four-helical cytokine-like, core |
| Interleukin-6-like |
| Interleukin-6/GCSF/MGF |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060688 | arteriovenous malformations of the brain | |
| DOID:0060901 | lymphoplasmacytic lymphoma | |
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:0080547 | metabolic dysfunction-associated steatohepatitis | |
| DOID:10140 | dry eye syndrome | |
| DOID:10534 | stomach cancer | |
| DOID:10608 | celiac disease | |
| DOID:10754 | otitis media | |
| DOID:10763 | hypertension | |
| DOID:10941 | intracranial aneurysm |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3569 | Xenbase:XB-GENE-480186 | ||
| 16193 | MOUSE45794 | ||
| 24498 | RATNO30110 | ||
| 280826 | BOVIN27769 | ||
| 403985 | CANLF03731 | ||
| 443406 | SHEEP15364 | ||
| 463288 | PANTR39808 | ||
| 493687 | FELCA05270 | ||
| 705819 | MACMU31900 | ||
| 100008733 | RABIT01514 |
