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interleukin 10 receptor subunit beta

Summary

Gene Symbol

IL10RB

Organism

Homo sapiens (human)

External Links

NCBI Gene

3588

PubChem

3588

Alliance of Genome Resources

HGNC:5965

JoGo

IL10RB

TogoVar

IL10RB

Annotation

Keyword

3D-structure
Antiviral defense
Direct protein sequencing
Disulfide bond
Glycoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A1B0GTI5	Cytokine receptor class-II member 4 Cytokine receptor family 2 member 4 Interleukin-10 receptor subunit 2
Q08334	Cytokine receptor class-II member 4 Cytokine receptor family 2 member 4 Interleukin-10 receptor subunit 2
A0A1B0GU52	Cytokine receptor class-II member 4 Cytokine receptor family 2 member 4 Interleukin-10 receptor subunit 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

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GO Term	Evidence Code	PMID
inflammatory response	TAS	10954742
immune response	TAS	9463407
signal transduction	TAS	10954742
cytokine-mediated signaling pathway	IBA
type III interferon-mediated signaling pathway	NAS	30936491

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

interleukin-10-mediated signaling pathway

interferon-mediated signaling pathway [inference]

type III interferon-mediated signaling pathway

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of generation of precursor metabolites and energy [inference]

regulation of cellular respiration [inference]

positive regulation of cellular respiration

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

interleukin-10-mediated signaling pathway

interferon-mediated signaling pathway [inference]

type III interferon-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

regulation of generation of precursor metabolites and energy [inference]

regulation of cellular respiration [inference]

positive regulation of cellular respiration

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cellular metabolic process [inference]

positive regulation of cellular respiration

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IC	16982608
plasma membrane	IBA
membrane	TAS	9312047
interleukin-28 receptor complex	NAS	12483210

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

interleukin-28 receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

interleukin-28 receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
interleukin-10 receptor activity	TAS	10954742
interleukin-10 receptor activity	IBA
protein binding	IPI	12483210 12513909 15120653 16982608 20462497
coreceptor activity	IDA	16982608
signaling receptor activity	TAS	8314576

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

interleukin-10 receptor activity

coreceptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

interleukin-10 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Interleukin-10 receptor subunit beta

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
interferon receptor activity
interleukin-10 receptor activity

Displaying **all 4** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Interferon/interleukin receptor domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0081267	graft-versus-host disease	Alliance of Genome Resources
DOID:0110909	inflammatory bowel disease 25	Alliance of Genome Resources
DOID:2043	hepatitis B	Alliance of Genome Resources