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Guidelines

MIRAGE

BSCL2 lipid droplet biogenesis associated, seipin

Summary

Gene Symbol

Bscl2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

361722

PubChem

361722

Alliance of Genome Resources

RGD:1308135

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Lipid degradation
Lipid droplet
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5FVJ6	Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
skeletal system development	ISO
tissue homeostasis	ISO
hair follicle development	ISO
lipid metabolic process	IEA
mitochondrion organization	ISO

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

reactive oxygen species metabolic process

primary metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

organic substance metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

spermatid differentiation

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

reactive oxygen species metabolic process

cellular developmental process [inference]

cell differentiation [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

maintenance of location in cell

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

lipid droplet organization

lipid droplet formation

chromosome organization

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

lipid droplet formation

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

lipid droplet formation

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatid differentiation

cellular process involved in reproduction in multicellular organism [inference]

spermatid differentiation

multicellular organismal process [inference]

determination of adult lifespan

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

multicellular organism growth

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatid differentiation

anatomical structure development [inference]

hair follicle development

tissue development [inference]

connective tissue development [inference]

adipose tissue development

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

system development [inference]

cellular developmental process [inference]

cell differentiation [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis

localization [inference]

maintenance of location [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

regulation of lipid catabolic process [inference]

negative regulation of lipid catabolic process

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of lipid catabolic process [inference]

negative regulation of lipid catabolic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity

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GO Term	Evidence Code	PMID
cytoplasm	ISO
endoplasmic reticulum	ISO
endoplasmic reticulum membrane	ISS
endoplasmic reticulum membrane	ISO
endoplasmic reticulum membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

lipid droplet

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phospholipid binding	ISO
phospholipid binding	IEA

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

phospholipid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Seipin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
lipid droplet formation
lipid droplet organization
lipid metabolic process
lipid storage

Displaying 1 entry
InterPro
Seipin family

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14227	azoospermia	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 48 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Carlito syrichta	103255635		CARSF21229
Ursus maritimus	103678197		URSMA29816
Nannospalax galili	103737672		NANGA22876
Rhinopithecus roxellana	104679338		RHIRO09080
Pteropus vampyrus	105297808		PTEVA11739
Macaca nemestrina	105469458		MACNE28758
Mandrillus leucophaeus	105549052		MANLE14393
Cercocebus atys	105577542		CERAT20901
Propithecus coquereli	105827154		PROCO11829
Equus asinus asinus	106826825		EQUAS31429

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025