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aquaporin 4

Summary

Gene Symbol

AQP4

Organism

Homo sapiens (human)

External Links

NCBI Gene

361

PubChem

361

Alliance of Genome Resources

HGNC:637

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cell projection
Disease variant
Endosome
Glycoprotein
Palmitate
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying **all 4** entries
UniProt	Protein Name
V9PBN7
F1DSG4
A0A5F9ZHR4
P55087	Mercurial-insensitive water channel WCH4

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cerebrospinal fluid circulation	ISS
intracellular water homeostasis	IMP ISS	37143309
multicellular organismal-level water homeostasis	IEP ISS	16814974 17645239
cellular response to type II interferon	IDA	17645239
transmembrane transport	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal water homeostasis

nervous system process [inference]

cerebrospinal fluid circulation

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

renal water homeostasis

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

intracellular chemical homeostasis [inference]

intracellular water homeostasis

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

renal water homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular water homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

renal water homeostasis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to type II interferon [inference]

cellular response to type II interferon

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

fluid transport [inference]

water transport

transmembrane transport

organic substance transport [inference]

water transport

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

multicellular organismal-level water homeostasis

renal water homeostasis

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

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GO Term	Evidence Code	PMID
external side of plasma membrane	IDA	17645239
sarcolemma	IDA	29055082
plasma membrane	IBA IDA TAS	16814974 37143309 8601457
extracellular region	IEA
astrocyte end-foot	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

sarcolemma

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

basolateral plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection [inference]

astrocyte projection [inference]

astrocyte end-foot

side of membrane [inference]

external side of plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25910212 28734904 31286866 32296183
identical protein binding	IPI	19383790
water channel activity	EXP IBA IDA IMP	17178220 18511455 19383790 37143309 8601457

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

water transmembrane transporter activity [inference]

water channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

water channel activity

salt transmembrane transporter activity [inference]

water transmembrane transporter activity [inference]

water channel activity

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aquaporin A

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
water channel activity

Displaying **all 4** entries
InterPro
Aquaporin transporter
Aquaporin-like
Major intrinsic protein, conserved site
Major intrinsic protein

Disease

Disease Ontology

Displaying entries **1 - 10** of 27 in total

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DO ID	Disease Name	Source
DOID:0080122	Alpers-Huttenlocher syndrome	Alliance of Genome Resources
DOID:0080315	megalencephalic leukoencephalopathy with subcortical cysts	Alliance of Genome Resources
DOID:0080743	transverse myelitis	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10908	hydrocephalus	Alliance of Genome Resources
DOID:1210	optic neuritis	Alliance of Genome Resources
DOID:12236	primary biliary cholangitis	Alliance of Genome Resources
DOID:12365	malaria	Alliance of Genome Resources
DOID:13141	uveitis	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of **112** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Papio anubis	101015807		PAPAN16895
Papio anubis	101018308		PAPAN16895
Saimiri boliviensis boliviensis	101038415		SAIBB08129
Takifugu rubripes	101062510		TAKRU00835
Felis catus	101081006		FELCA27642
Gorilla gorilla gorilla	101144332	9595_0:0049d1	GORGO13890
Oryzias latipes	101164753		ORYLA06983
Tursiops truncatus	101334445		TURTR01294
Octodon degus	101565015		OCTDE00447
Jaculus jaculus	101596800		JACJA06035

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OrthoDB (Group)

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Acknowledgements