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fibronectin leucine rich transmembrane protein 3

Summary

Gene Symbol

Flrt3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

366205

PubChem

366205

Alliance of Genome Resources

RGD:1566005

Annotation

Keyword

Cell adhesion
Cell junction
Cell membrane
Cell projection
Cytoplasmic vesicle
Developmental protein
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Leucine-rich repeat
Reference proteome
Repeat
Secreted
Signal
Synaptosome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
B1H234	Fibronectin-like domain-containing leucine-rich transmembrane protein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
head development	ISO ISS
synapse assembly	ISO ISS
fibroblast growth factor receptor signaling pathway	ISO ISS
neuron projection extension	IMP ISO	15485775
heart development	ISO ISS

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules

synaptic membrane adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

cell motility [inference]

cell migration [inference]

cell migration involved in heart development [inference]

proepicardium cell migration involved in pericardium morphogenesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization

synapse assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis

anatomical structure development [inference]

animal organ development [inference]

heart development

head development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth involved in morphogenesis [inference]

neuron projection extension

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

response to axon injury

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
axon terminus	IDA	15485775
cell junction	ISO
cytoplasmic vesicle	IEA
postsynaptic membrane	ISO
focal adhesion	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

plasma membrane region [inference]

synaptic membrane

cell junction

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-cell junction

cell-substrate junction [inference]

focal adhesion

site of polarized growth [inference]

growth cone [inference]

axonal growth cone

growth cone membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

postsynaptic specialization [inference]

postsynaptic density

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
fibroblast growth factor receptor binding	ISO
chemorepellent activity	ISO
protein homodimerization activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

chemorepellent activity

growth factor receptor binding [inference]

fibroblast growth factor receptor binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Leucine-rich repeat

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 8** entries
InterPro
Cysteine-rich flanking region, C-terminal
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Leucine-rich repeat N-terminal domain
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090093	hypogonadotropic hypogonadism 21 with or without anosmia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **128** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	23767		HGNC:3762	HUMAN56146
Mus musculus	71436	10090_1:0005fc	MGI:1918686	MOUSE35580
Pan troglodytes	469886			PANTR24388
Canis lupus familiaris	477149			CANLF09282
Bos taurus	529416			BOVIN04240
Danio rerio	558864		ZFIN:ZDB-GENE-030131-1988	DANRE05610
Macaca mulatta	694694			MACMU01115
Monodelphis domestica	100031549			MONDO08905
Equus caballus	100051056			HORSE21176
Ornithorhynchus anatinus	100084753			ORNAN26709