GlyCosmos Portal

Submissions

keratin 2

Summary

Gene Symbol

KRT2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3849

PubChem

3849

Alliance of Genome Resources

HGNC:6439

Annotation

Keyword

Coiled coil
Cytoplasm
Disease variant
Ichthyosis
Intermediate filament
Keratin
Methylation
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P35908	Cytokeratin-2e Epithelial keratin-2e Keratin-2 epidermis Keratin-2e Type-II keratin Kb2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
keratinocyte development	IEA
intermediate filament organization	IBA
keratinization	IBA IDA	12598329
epidermis development	TAS	7524919
keratinocyte migration	IDA	15737202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

macromolecule modification [inference]

protein modification process [inference]

peptide cross-linking

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

cellular process [inference]

cell activation [inference]

keratinocyte activation

cell population proliferation [inference]

epithelial cell proliferation [inference]

keratinocyte proliferation

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

keratinocyte development

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

keratinocyte migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

supramolecular fiber organization [inference]

intermediate filament organization

multicellular organismal process [inference]

cell activation [inference]

keratinocyte activation

keratinization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

cell development [inference]

epithelial cell development [inference]

keratinocyte development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

keratinocyte development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of epidermis development

regulation of developmental process [inference]

regulation of epidermis development [inference]

positive regulation of epidermis development

positive regulation of developmental process [inference]

positive regulation of epidermis development

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
intermediate filament	TAS	1380918
nucleus	HDA	21630459
intermediate filament cytoskeleton	IDA
cytoplasm	IDA	32179842
extracellular space	HDA	23580065

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane [inference]

cornified envelope

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

keratin filament

Displaying **all 4** entries
GO Term	Evidence Code	PMID
structural constituent of skin epidermis	IBA IDA	7543090
protein binding	IPI	25416956 25910212 29892012 31515488 32296183
cytoskeletal protein binding	IEA
structural constituent of cytoskeleton	TAS	1380918

GO Hierarchy

molecular function

structural molecule activity [inference]

binding [inference]

protein binding

cytoskeletal protein binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060877	bullous congenital ichthyosiform erythroderma	Alliance of Genome Resources
DOID:1697	ichthyosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 58 in total

1

2

3

4

5

6

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	3848	Xenbase:XB-GENE-876590
Xenopus tropicalis	3849	Xenbase:XB-GENE-876590
Xenopus tropicalis	3852	Xenbase:XB-GENE-6035591
Danio rerio	3855	ZFIN:ZDB-GENE-991110-23
Danio rerio	3856	ZFIN:ZDB-GENE-991110-23
Caenorhabditis elegans	3858	WB:WBGene00002056
Xenopus tropicalis	9119	Xenbase:XB-GENE-6035591
Caenorhabditis elegans	13346	WB:WBGene00002055
Caenorhabditis elegans	14580	WB:WBGene00002055
Xenopus tropicalis	16678	Xenbase:XB-GENE-6035591

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements