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keratin 10

Summary

Gene Symbol

KRT10

Organism

Homo sapiens (human)

External Links

NCBI Gene

3858

PubChem

3858

Alliance of Genome Resources

HGNC:6413

Annotation

Keyword

3D-structure
Coiled coil
Cytoplasm
Direct protein sequencing
Disease variant
Disulfide bond
Ichthyosis
Intermediate filament
Keratin
Phosphoprotein
Reference proteome
Secreted

Proteins

Displaying 1 entry
UniProt	Protein Name
P13645	Cytokeratin-10 Keratin-10

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
epithelial cell differentiation	IBA
intermediate filament organization	IBA
epidermis development	IBA
protein heterotetramerization	IDA	27595935
positive regulation of epidermis development	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

macromolecule modification [inference]

protein modification process [inference]

peptide cross-linking

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

cellular process [inference]

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

epidermal cell differentiation [inference]

keratinocyte differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization [inference]

protein heterotetramerization

protein heterooligomerization [inference]

protein heterotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization [inference]

protein heterotetramerization

protein heterooligomerization [inference]

protein heterotetramerization

supramolecular fiber organization [inference]

intermediate filament organization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

epidermal cell differentiation [inference]

keratinocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of epidermis development

regulation of developmental process [inference]

regulation of epidermis development [inference]

positive regulation of epidermis development

positive regulation of developmental process [inference]

positive regulation of epidermis development

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
intermediate filament	NAS	2459124
nucleus	HDA	21630459
cytoplasm	IDA	22170488 32179842
extracellular space	HDA	23580065
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane [inference]

cornified envelope

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

keratin filament

Displaying **all 3** entries
GO Term	Evidence Code	PMID
structural constituent of skin epidermis	IBA IDA NAS	2459124 7543090
protein heterodimerization activity	IDA	27595935
protein binding	IPI	19627498 24940650 27595935

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of skin epidermis

binding [inference]

protein binding

protein dimerization activity [inference]

protein heterodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0081359	epidermolytic hyperkeratosis 2	Alliance of Genome Resources
DOID:4603	epidermolytic hyperkeratosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	3848	WB:WBGene00002056
Caenorhabditis elegans	3849	WB:WBGene00002056
Caenorhabditis elegans	3852	WB:WBGene00002056
Xenopus tropicalis	3858	Xenbase:XB-GENE-920273
Danio rerio	3860	ZFIN:ZDB-GENE-991008-6
Danio rerio	3872	ZFIN:ZDB-GENE-991008-6
Danio rerio	3880	ZFIN:ZDB-GENE-991008-6
Caenorhabditis elegans	9119	WB:WBGene00002056
Caenorhabditis elegans	13346	WB:WBGene00002055
Caenorhabditis elegans	14580	WB:WBGene00002055