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C-type lectin domain family 12 member B

Summary

Gene Symbol

CLEC12B

Organism

Homo sapiens (human)

External Links

NCBI Gene

387837

HGNC

31966

KEGG Gene ID

hsa:387837

PubChem

387837

Alliance of Genome Resources

HGNC:31966

Annotation

Keyword

Alternative splicing
Cell membrane
Coiled coil
Disulfide bond
Glycoprotein
Lectin
Phosphoprotein
Receptor
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A140VK10
Q2HXU8	Macrophage antigen H

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
negative regulation of signaling receptor activity	IBA IMP	17562706
negative regulation of receptor signaling pathway via STAT	IDA	34310951
negative regulation of natural killer cell mediated cytotoxicity	IMP	17562706
melanocyte proliferation	IDA	34310951
natural killer cell inhibitory signaling pathway	IBA IMP	17562706

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-inhibiting signal transduction [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

cell population proliferation [inference]

epithelial cell proliferation [inference]

melanocyte proliferation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of leukocyte mediated immunity [inference]

regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of lymphocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-inhibiting signal transduction [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

regulation of signaling receptor activity [inference]

negative regulation of signaling receptor activity

regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

regulation of signaling receptor activity [inference]

negative regulation of signaling receptor activity

regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via STAT

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-inhibiting signal transduction [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-inhibiting signal transduction [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

regulation of signaling receptor activity [inference]

negative regulation of signaling receptor activity

regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

regulation of cell killing [inference]

regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

negative regulation of signaling receptor activity

negative regulation of molecular function [inference]

negative regulation of signaling receptor activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA IMP	17562706
protein-containing complex	IMP	17562706

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

side of membrane [inference]

external side of plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
signaling receptor inhibitor activity	IMP	17562706
carbohydrate binding	IEA
protein phosphatase binding	IBA IDA IPI	17562706 34310951

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

carbohydrate binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor inhibitor activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K17517

Name

C-type lectin domain family 12 member B

References

17562706

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:162	cancer	DisGeNET
DOID:4766	embryoma	DisGeNET
DOID:7439	polyp of middle ear	DisGeNET
DOID:869	cholesteatoma	DisGeNET

Ortholog

Displaying entries **21 - 30** of 40 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Loxodonta africana	100660677		LOXAF14157
Sus scrofa	100519958		PIGXX26198
Bos taurus	616085		BOVIN30286
Capra hircus	102187464		CAPHI25408
Oryctolagus cuniculus	100342539		RABIT12266
Cricetulus griseus	100772182		CRIGR19029
Mus musculus	71183	MGI:1918433	MOUSE49205
Rattus norvegicus	502900	RGD:1560487	RATNO31484
Octodon degus	101578043		OCTDE03196
Bos indicus x Bos taurus	113893629		BOBOX40977

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements