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Peptidoglycan recognition protein LA

Summary

Gene Symbol

PGRP-LA

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

39062

PubChem

39062

Alliance of Genome Resources

FB:FBgn0035975

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Innate immunity
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
M9PEM5
Q95T64

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
peptidoglycan catabolic process	IKR IMR	12496260
defense response to Gram-negative bacterium	IEP	23922788
immune response	ISS	11106397
response to bacterium	IDA	19237508
positive regulation of peptidoglycan recognition protein signaling pathway	IMP	23922788

GO Hierarchy

biological process

immune system process [inference]

immune response

innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

innate immune response

immune response

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane		11106397

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
zinc ion binding	IEA
N-acetylmuramoyl-L-alanine amidase activity	IKR IMR	12496260
peptidoglycan binding	IKR IMR	23922788

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

N-acetylmuramoyl-L-alanine amidase activity

peptidoglycan muralytic activity [inference]

N-acetylmuramoyl-L-alanine amidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

peptidoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
membrane	FB:FBrf0231198

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Danio rerio	568634	ZFIN:ZDB-GENE-071227-1
Danio rerio	571817	ZFIN:ZDB-GENE-071227-2
Homo sapiens	114770	HGNC:30013
Mus musculus	57757	MGI:1928099
Rattus norvegicus	299567	RGD:1359183

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements