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dual oxidase 2

Summary

Gene Symbol

DUOX2

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 397060
PubChem: 397060

Annotation

Keyword

Calcium
Cell junction
Cell membrane
Disulfide bond
FAD
Glycoprotein
Hydrogen peroxide
Metal-binding
NADP
Reference proteome
Repeat
Signal
Thyroid hormones biosynthesis
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8HZK2	NADH/NADPH thyroid oxidase p138-tox

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cuticle development
superoxide anion generation	IEA	30032202
hydrogen peroxide catabolic process
defense response	IEA	30032202
response to cAMP

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

biosynthetic process [inference]

hormone biosynthetic process

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

hormone biosynthetic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

developmental process [inference]

anatomical structure development [inference]

cuticle development

response to stimulus [inference]

response to stress [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organophosphorus [inference]

response to cAMP

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to oxygen-containing compound [inference]

response to cAMP

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

hormone biosynthetic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
anchoring junction
apical plasma membrane
NADPH oxidase complex	IEA	30032202
plasma membrane	IEA	30032202
endoplasmic reticulum

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

NADPH oxidase complex

catalytic complex [inference]

oxidoreductase complex [inference]

NADPH oxidase complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

anchoring junction

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

apical part of cell

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
superoxide-generating NAD(P)H oxidase activity	IEA	30032202
peroxidase activity	IEA	22301074
NADH oxidase H202-forming activity
NADPH oxidase H202-forming activity
heme binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [inference]

NAD(P)H oxidase H2O2-forming activity [inference]

superoxide-generating NAD(P)H oxidase activity

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dual oxidase

Functional Category

P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
calcium ion binding
cellular oxidant detoxification
heme binding
metal ion binding
oxidoreductase activity
response to oxidative stress
superoxide anion generation
superoxide-generating NAD(P)H oxidase activity

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InterPro
EF-Hand 1, calcium-binding site
EF-hand domain pair
EF-hand domain
FAD-binding 8
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Ferric reductase transmembrane component-like domain
Ferric reductase, NAD binding domain
Haem peroxidase domain superfamily, animal type
Haem peroxidase superfamily

Ortholog

Displaying entries **41 - 50** of 87 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Lepisosteus oculatus	102686607			LEPOC11873
Physeter catodon	102980878	9755_0:00211f
Erinaceus europaeus	103123470			ERIEU09701
Callorhinchus milii	103188862			CALMI04281
Chlorocebus sabaeus	103245704			CHLSB12690
Carlito syrichta	103264967			CARSF19475
Nannospalax galili	103746898			NANGA09344
Serinus canaria	103816154			SERCA10186
Rhinopithecus roxellana	104653891			RHIRO39393
Bison bison bison	104994233	43346_0:002978

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024