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fatty acid synthase

Summary

Gene Symbol

FASN

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 397561
KEGG Gene ID: ssc:397561
PubChem: 397561

Annotation

Keyword

3D-structure
Acetylation
Fatty acid biosynthesis
Hydrolase
Lyase
Multifunctional enzyme
NAD
NADP
Nucleotide-binding
Phosphopantetheine
Phosphoprotein
Pyridoxal phosphate
S-nitrosylation
Transferase

Proteins

Displaying 1 entry
UniProt	Protein Name
A5YV76

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
fatty acid biosynthetic process	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytoplasm	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

Displaying **all 4** entries
GO Term	Evidence Code	PMID
oxidoreductase activity	IEA	22301074
fatty acid synthase activity	IEA	30032202
phosphopantetheine binding	IEA	22301074
3-oxoacyl-[acyl-carrier-protein] synthase activity	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

binding [inference]

amide binding [inference]

phosphopantetheine binding

small molecule binding [inference]

vitamin binding [inference]

phosphopantetheine binding

modified amino acid binding [inference]

phosphopantetheine binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00665

Name

fatty acid synthase, animal type [EC:2.3.1.85]

References

2717611

Rhea

H₂O

H⁺ + tetradecanoate

Enzyme

3.1.2.14

PMID

16107329

NADP⁺

H⁺ + NADPH

Enzyme

1.1.1.100

PMID

malonyl-CoA

CoA

Enzyme

2.3.1.39

PMID

acetyl-CoA

CoA

Enzyme

2.3.1.38

PMID

H⁺

CO₂

Enzyme

2.3.1.41

PMID

H₂O

H⁺ + hexadecanoate

Enzyme

3.1.2.14

PMID

H₂O

H⁺ + (9Z)-octadecenoate

Enzyme

3.1.2.14

PMID

NADP⁺

H⁺ + NADPH

Enzyme

PMID

H⁺ + acetyl-CoA + malonyl-CoA + NADPH

CO₂ + CoA + a long-chain fatty acid + NADP⁺

Enzyme

2.3.1.85

PMID

Ortholog

Displaying entries **1 - 10** of 64 in total

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Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callorhinchus milii	103175468		CALMI08071
Latimeria chalumnae	102352909		LATCH18314
Astyanax mexicanus	103030617		ASTMX12636
Ictalurus punctatus	108273998		ICTPU04846
Salmo salar	106610271		SALSA66834
Salmo trutta	115152886		SALTR08560
Salmo trutta	115201394		SALTR100275
Chrysemys picta bellii	101942965		CHRPI03818
Crocodylus porosus	109324496		CROPO27006
Pseudonaja textilis	113437083		PSETE08446

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024