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gremlin 1, DAN family BMP antagonist L homeolog

Summary

Gene Symbol

grem1.L

Organism

Xenopus laevis (African clawed frog)

External Links

NCBI Gene

399094

PubChem

399094

Alliance of Genome Resources

Xenbase:XB-GENE-865098

Annotation

Keyword

Cytokine
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7ZQZ5
A0A974C8W7
O73754	Cysteine knot superfamily 1, BMP antagonist 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nervous system development	IMP	9660951
animal organ morphogenesis
neural crest formation	IEP	9660951
neural crest cell development	IEP	9660951
somite rostral/caudal axis specification	IMP	9660951

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition [inference]

neural crest formation

cell development [inference]

stem cell development [inference]

neural crest cell development

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation [inference]

determination of dorsal identity

axis specification [inference]

embryonic axis specification [inference]

somite rostral/caudal axis specification

anterior/posterior axis specification [inference]

somite rostral/caudal axis specification

embryonic pattern specification [inference]

embryonic axis specification [inference]

somite rostral/caudal axis specification

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

anatomical structure formation involved in morphogenesis [inference]

neural crest formation

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

kidney epithelium development [inference]

nephric duct development [inference]

pronephric duct development

tube development [inference]

nephric duct development [inference]

pronephric duct development

cell development [inference]

stem cell development [inference]

neural crest cell development

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition [inference]

neural crest formation

cell development [inference]

stem cell development [inference]

neural crest cell development

localization [inference]

maintenance of location [inference]

maintenance of protein location [inference]

maintenance of protein location in extracellular region [inference]

sequestering of BMP in extracellular matrix

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

delamination [inference]

neural crest cell delamination

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway [inference]

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway [inference]

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

delamination [inference]

neural crest cell delamination

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

delamination [inference]

neural crest cell delamination

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

delamination [inference]

neural crest cell delamination

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
extracellular space	IDA	9660951
extracellular space	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytokine activity	IEA
morphogen activity	IDA	9660951
BMP binding	IDA	9660951
heparan sulfate proteoglycan binding	IMP	31883440

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

cytokine binding [inference]

BMP binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

carbohydrate derivative binding [inference]

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

heparan sulfate proteoglycan binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

gremlin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
BMP binding
animal organ morphogenesis
sequestering of BMP from receptor via BMP binding

Displaying **all 3** entries
InterPro
Cystine knot, C-terminal
Cystine-knot cytokine
DAN

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	23892	Xenbase:XB-GENE-484543
Xenopus tropicalis	26585	Xenbase:XB-GENE-484543
Xenopus tropicalis	50566	Xenbase:XB-GENE-484543
Xenopus tropicalis	399094	Xenbase:XB-GENE-484543

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements