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LDL receptor related protein associated protein 1

Summary

Gene Symbol

LRPAP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4043

PubChem

4043

Alliance of Genome Resources

HGNC:6701

Annotation

Keyword

3D-structure
Coiled coil
Direct protein sequencing
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Heparin-binding
Phosphoprotein
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P30533	Low density lipoprotein receptor-related protein-associated protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
negative regulation of receptor internalization	IGI	23386614
negative regulation of receptor internalization	IBA
signal transduction	IDA	11294867
negative regulation of very-low-density lipoprotein particle clearance	IDA	8083232
negative regulation of very-low-density lipoprotein particle clearance	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

vesicle-mediated transport [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

multicellular organismal process [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

amyloid-beta clearance [inference]

amyloid-beta clearance by transcytosis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of amyloid-beta clearance

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of amyloid-beta clearance

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

regulation of very-low-density lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

positive regulation of multicellular organismal process [inference]

positive regulation of amyloid-beta clearance

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of amyloid-beta clearance

regulation of amyloid-beta clearance [inference]

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of binding [inference]

negative regulation of protein binding

regulation of binding [inference]

regulation of protein binding [inference]

negative regulation of protein binding

negative regulation of binding [inference]

negative regulation of protein binding

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS	14645246
endosome	IDA	7774585
endosome	IBA
endoplasmic reticulum	IDA
endoplasmic reticulum-Golgi intermediate compartment	IDA	7774585

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen [inference]

rough endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
amyloid-beta binding	TAS	22383525
signaling receptor binding	TAS	14645246
protein binding	IPI	10085125 11294867 17326667 18687776 19122660 20030366 20223215 20584990 26858303 28514442 32296183 32814053 33961781 8083232
heparin binding	IEA
lipase binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

lipoprotein particle receptor binding [inference]

enzyme binding [inference]

lipase binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

signaling receptor inhibitor activity [inference]

receptor antagonist activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity [inference]

receptor antagonist activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-2-macroglobulin receptor-associated protein

Functional Category

I: Lipid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
heparin binding
lipase binding
low-density lipoprotein particle receptor binding
negative regulation of receptor internalization
negative regulation of very-low-density lipoprotein particle clearance
receptor antagonist activity
very-low-density lipoprotein particle receptor binding

Displaying **all 5** entries
InterPro
Alpha-2-macroglobulin RAP, C-terminal
Alpha-2-macroglobulin RAP, domain 3
Alpha-2-macroglobulin receptor-associated protein, domain 1
Alpha-2-macroglobulin receptor-associated protein
RAP domain superfamily

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:11830	myopia	Alliance of Genome Resources
DOID:1307	dementia	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4043	Xenbase:XB-GENE-946427
Mus musculus	16976	Xenbase:XB-GENE-946427	MOUSE44390
Rattus norvegicus	116565	Xenbase:XB-GENE-946427	RATNO08290
Danio rerio	333939		DANRE49169
Sus scrofa	399654		PIGXX33234
Pan troglodytes	461086		PANTR33213
Canis lupus familiaris	479072		CANLF12162
Macaca mulatta	699677		MACMU35838
Monodelphis domestica	100020963		MONDO28034
Pongo abelii	100172021		PONAB27621