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LDL receptor related protein associated protein 1

Summary

Gene Symbol

LRPAP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4043

PubChem

4043

Alliance of Genome Resources

HGNC:6701

JoGo

LRPAP1

TogoVar

LRPAP1

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
negative regulation of receptor internalization	IGI	23386614
negative regulation of receptor internalization	IBA
signal transduction	IDA	11294867
negative regulation of very-low-density lipoprotein particle clearance	IDA	8083232
negative regulation of very-low-density lipoprotein particle clearance	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

vesicle-mediated transport [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

multicellular organismal process [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

amyloid-beta clearance [inference]

amyloid-beta clearance by transcytosis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of amyloid-beta clearance

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of amyloid-beta clearance

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

regulation of very-low-density lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

positive regulation of multicellular organismal process [inference]

positive regulation of amyloid-beta clearance

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of amyloid-beta clearance

regulation of amyloid-beta clearance [inference]

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of binding [inference]

negative regulation of protein binding

regulation of binding [inference]

regulation of protein binding [inference]

negative regulation of protein binding

negative regulation of binding [inference]

negative regulation of protein binding

Displaying entries **6 - 10** of 17 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum-Golgi intermediate compartment	IBA
Golgi apparatus	IDA	7774585
Golgi lumen	IEA
cis-Golgi network	IDA	7774585
cis-Golgi network	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen [inference]

rough endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
amyloid-beta binding	TAS	22383525
signaling receptor binding	TAS	14645246
protein binding	IPI	10085125 11294867 17326667 18687776 19122660 20030366 20223215 20584990 26858303 28514442 32296183 32814053 33961781 8083232
heparin binding	IEA
lipase binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

lipoprotein particle receptor binding [inference]

enzyme binding [inference]

lipase binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

signaling receptor inhibitor activity [inference]

receptor antagonist activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity [inference]

receptor antagonist activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:11830	myopia	Alliance of Genome Resources
DOID:1307	dementia	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources