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mannosidase alpha class 2A member 1

Summary

Gene Symbol

MAN2A1

Aliases

GOLIM7
golgi integral membrane protein 7

Organism

Homo sapiens (human)

External Links

NCBI Gene

4124

HGNC

6824

KEGG Gene ID

hsa:4124

PubChem

4124

Alliance of Genome Resources

HGNC:6824

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosidase
Golgi apparatus
Metal-binding
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q16706	Golgi alpha-mannosidase II Mannosidase alpha class 2A member 1 Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
protein glycosylation	IEA
positive regulation of neurogenesis	IEA
vacuole organization	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein modification process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein modification process [inference]

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein modification process [inference]

macromolecule modification [inference]

protein modification process [inference]

macromolecule glycosylation [inference]

protein glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein modification process [inference]

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

viral process [inference]

viral protein processing

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

respiratory gaseous exchange by respiratory system

developmental process [inference]

anatomical structure morphogenesis [inference]

retina morphogenesis in camera-type eye

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

lung alveolus development

animal organ development [inference]

gland development [inference]

liver development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of cellular process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

Displaying **all 5** entries
GO Term	Evidence Code	PMID
Golgi medial cisterna	IDA	21525244
cis-Golgi network	IEA
membrane	HDA	19946888
extracellular exosome	HDA	19056867 19199708 23533145
Golgi membrane	IBA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi cisterna [inference]

Golgi medial cisterna

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

cis-Golgi network

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

cis-Golgi network

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
alpha-mannosidase activity	IBA TAS
protein homodimerization activity	IEA
metal ion binding	IEA
hydrolase activity, hydrolyzing N-glycosyl compounds	IEA
carbohydrate binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity [inference]

alpha-mannosidase activity

mannosyl-oligosaccharide mannosidase activity [inference]

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

hydrolase activity, hydrolyzing N-glycosyl compounds

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000112893

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01231

Name

alpha-mannosidase II [EC:3.2.1.114]

References

8524845

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05984	3.2.1.114	G08520NM	G61751GZ

Rhea

H₂O

α-D-mannopyranose

Enzyme

3.2.1.114

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 19 in total

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DO ID	Disease Name	Source
DOID:0080144	childhood acute lymphocytic leukemia	DisGeNET
DOID:0111401	congenital dyserythropoietic anemia type II	DisGeNET
DOID:10283	prostate cancer	DisGeNET DisGeNET
DOID:10286	prostate carcinoma	DisGeNET DisGeNET
DOID:1338	congenital dyserythropoietic anemia	DisGeNET DisGeNET Alliance of Genome Resources
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:2914	immune system disease	DisGeNET
DOID:3068	glioblastoma	DisGeNET DisGeNET
DOID:3070	high grade glioma	DisGeNET
DOID:3074	giant cell glioblastoma	DisGeNET DisGeNET

Ortholog

Displaying entries **61 - 70** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Myotis lucifugus	102435674		MYOLU00132
Rhinolophus ferrumequinum	117024814		RHIFE12806
Taeniopygia guttata	100227845		TAEGU31634
Chlorocebus sabaeus	103244316		CHLSB10842
Rhinopithecus roxellana	104675604		RHIRO29351
Nomascus leucogenys	100581120		NOMLE25899
Podarcis muralis	114606107		PODMU09924
Sinocyclocheilus grahami	107564047		SINGR88370
Sinocyclocheilus grahami	107603169		SINGR88370
Equus asinus asinus	106832412		EQUAS05196

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Last updated: August 19, 2024