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melanocortin 2 receptor

Summary

Gene Symbol

MC2R

Organism

Homo sapiens (human)

External Links

NCBI Gene

4158

PubChem

4158

Alliance of Genome Resources

HGNC:6930

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q01718	Adrenocorticotropin receptor Melanocortin receptor 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	TAS	1325670
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	9175632
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	19329486
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
neuropeptide signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
plasma membrane	TAS
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IBA
melanocortin receptor activity	TAS	1325670
corticotropin receptor activity	IEA
protein binding	IPI	18077336 18840636 19151134 19329486 28298427

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

melanocortin receptor activity

corticotropin receptor activity

neuropeptide receptor activity [inference]

corticotropin receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled peptide receptor activity [inference]

melanocortin receptor activity

corticotropin receptor activity

neuropeptide receptor activity [inference]

corticotropin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

g_PROTEIN_RECEP_F1_2 domain-containing protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050562	West syndrome	Alliance of Genome Resources
DOID:0080621	glucocorticoid deficiency 1	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 64 in total

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Species	Gene ID	Orthologous MAtrix
Cricetulus griseus	100757427	CRIGR15469
Canis lupus familiaris	100855756	CANLF00109
Sarcophilus harrisii	100915134	SARHA16440
Otolemur garnettii	100942974	OTOGA02570
Pan paniscus	100987960	PANPA18275
Gorilla gorilla gorilla	101143835	GORGO14221
Tursiops truncatus	101317693	TURTR02123
Octodon degus	101588367	OCTDE26829
Jaculus jaculus	101610997	JACJA08167
Mustela putorius furo	101676754	MUSPF17606

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements