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melanocortin 2 receptor

Summary

Gene Symbol

MC2R

Organism

Homo sapiens (human)

External Links

NCBI Gene

4158

PubChem

4158

Alliance of Genome Resources

HGNC:6930

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q01718	Adrenocorticotropin receptor Melanocortin receptor 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
neuropeptide signaling pathway	IEA
regulation of metabolic process	IBA
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	9175632
G protein-coupled receptor signaling pathway	TAS	1325670
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA IDA	19329486

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA TAS
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18077336 18840636 19151134 19329486 28298427
melanocortin receptor activity	TAS	1325670
corticotropin receptor activity	IEA
G protein-coupled receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

melanocortin receptor activity

corticotropin receptor activity

neuropeptide receptor activity [inference]

corticotropin receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled peptide receptor activity [inference]

melanocortin receptor activity

corticotropin receptor activity

neuropeptide receptor activity [inference]

corticotropin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

g_PROTEIN_RECEP_F1_2 domain-containing protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050562	West syndrome	Alliance of Genome Resources
DOID:0080621	glucocorticoid deficiency 1	Alliance of Genome Resources
DOID:14115	toxic shock syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 66 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Cricetulus griseus	100757427		CRIGR15469
Canis lupus familiaris	100855756		CANLF00109
Sarcophilus harrisii	100915134		SARHA16440
Otolemur garnettii	100942974		OTOGA02570
Pan paniscus	100987960	9597_0:00487d	PANPA18275
Gorilla gorilla gorilla	101143835	9595_0:004b43	GORGO14221
Tursiops truncatus	101317693		TURTR02123
Octodon degus	101588367		OCTDE26829
Jaculus jaculus	101610997		JACJA08167
Mustela putorius furo	101676754		MUSPF17606

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements