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ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)

Summary

Gene Symbol

ART4

Aliases

ARTC4
CD297
DOK1
NAD(+)--protein-arginine ADP-ribosyltransferase 4

Organism

Homo sapiens (human)

External Links

NCBI Gene

420

HGNC

726

KEGG Gene ID

hsa:420

PubChem

420

Alliance of Genome Resources

HGNC:726

Annotation

Keyword

Blood group antigen
Cell membrane
Disulfide bond
GPI-anchor
Glycosyltransferase
NAD
NADP
Nucleotidyltransferase
Proteomics identification
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q93070	ADP-ribosyltransferase C2 and C3 toxin-like 4 Dombrock blood group carrier molecule Mono(ADP-ribosyl)transferase 4 NAD(P)(+)--arginine ADP-ribosyltransferase 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
arginine metabolic process	NAS	11001920

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

arginine metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

arginine metabolic process

primary metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

arginine metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

arginine metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

arginine metabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

arginine metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

arginine metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
plasma membrane	TAS
side of membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

side of membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
NAD+ ADP-ribosyltransferase activity	IBA
nucleotidyltransferase activity	IEA
NAD+-protein-arginine ADP-ribosyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

NAD+ ADP-ribosyltransferase activity

NAD+-protein ADP-ribosyltransferase activity [inference]

NAD+-protein-arginine ADP-ribosyltransferase activity

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity

catalytic activity, acting on a protein [inference]

NAD+-protein ADP-ribosyltransferase activity [inference]

NAD+-protein-arginine ADP-ribosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ADP ribosyltransferase

Functional Category

L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
NAD+ ADP-ribosyltransferase activity
nucleotidyltransferase activity
transferase activity

Displaying 1 entry
InterPro
NAD

KEGG BRITE Database

Orthology

K06717

Name

ADP-ribosyltransferase 4 [EC:2.4.2.31]

References

Rhea

RHEA:19149

NAD⁺

H⁺ + nicotinamide

Enzyme

2.4.2.31

PMID

RHEA:54884

NADP⁺

H⁺ + nicotinamide

Enzyme

2.4.2.31

PMID

225315

Disease

PubChem Disease

MedGen Diseases

Blood group, Dombrock system

OMIM Phenotypes

BLOOD GROUP, DOMBROCK SYSTEM; DO

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **41 - 50** of 55 in total

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Species	Gene ID	Orthologous MAtrix
Rhinopithecus roxellana	104666387	RHIRO20843
Pteropus vampyrus	105302772	PTEVA15727
Macaca nemestrina	105481776	MACNE32464
Mandrillus leucophaeus	105547277	MANLE22714
Cercocebus atys	105585114	CERAT17855
Aotus nancymaae	105713880	AOTNA19116
Microcebus murinus	105865291	MICMU12177
Equus asinus asinus	106826735	EQUAS05466
Rhinopithecus bieti	108530556	RHIBE08258
Capra hircus	108636043	CAPHI25325

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UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements