alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Summary
Gene Symbol
  • MGAT2
Aliases
  • GNT-II
Organism
Homo sapiens (human)
External Links
NCBI Gene
4247
GGDB ID
HGNC
7045
mRNA
map
  • 14q21
Protein
OMIM
KEGG Gene ID
hsa:4247
PubChem
4247
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Congenital disorder of glycosylation
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Glycosyltransferase
  • Golgi apparatus
  • Manganese
  • Metal-binding
  • Reference proteome
  • Signal-anchor
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
Q10469
  • Beta-1,2-N-acetylglucosaminyltransferase II
  • GlcNAc-T II
  • Mannoside acetylglucosaminyltransferase 2
  • N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000168282

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

GlycoGene Database (GGDB)
GGDB ID
gg126
Gene Symbol
  • MGAT2
Reactions
Displaying 1 entry
Donor Acceptor Product Reference
UDP-GlcNAc
G61751GZ
G39213VZ
Displaying all 3 entries
Donor Acceptor Product Reference
UDP-GlcNAc
G61751GZ
G39213VZ
UDP-GlcNAc
G07483YN
G80858MF
UDP-GlcNAc
G64272SY
G48524PJ
Orthologous Gene
KEGG BRITE Database
Orthology
K00736
Name
alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [EC:2.4.1.143]
References
Reactions
Displaying 1 entry
KEGG Reaction Enzyme Acceptor Product
R05985
Disease
Disease Ontology
Displaying entries 1 - 10 of 33 in total
DO ID Disease Name Source
DOID:2452 thrombophilia
DOID:0014667 disease of metabolism
DOID:0050571 congenital disorder of glycosylation type II
DOID:0060823 syndromic X-linked intellectual disability 94
DOID:0070194 autosomal recessive chronic granulomatous disease 3
DOID:0070253 congenital disorder of glycosylation type IIa
DOID:0111401 congenital dyserythropoietic anemia type II
DOID:10003 sensorineural hearing loss
DOID:10907 microcephaly
DOID:11714 gestational diabetes
The Human Phenotype Ontology
Displaying entries 1 - 10 of 98 in total
HPO ID HPO Term
HP:0000007 Autosomal recessive inheritance
HP:0000154 Wide mouth
HP:0000194 Open mouth
HP:0000212 Gingival overgrowth
HP:0000232 Everted lower lip vermilion
HP:0000233 Thin vermilion border
HP:0000248 Brachycephaly
HP:0000252 Microcephaly
HP:0000253 Progressive microcephaly
HP:0000256 Macrocephaly
Displaying all 2 entries
Disease ID Disease Name
ORPHA:79329
  • MGAT2-congenital disorder of glycosylation
OMIM:212066
  • MGAT2-congenital disorder of glycosylation

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024