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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Summary
- UniProt ID
- Q10469
- Gene Symbol
-
- MGAT2
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q10469
- PubChem
- Q10469
- The Human Metabolome Database
- HMDBP01609
- The O-GlcNAc Database
- Q10469
- O-GlcNAcAtlas
- Q10469
Annotation
- Keyword
-
- 3D-structure
- Congenital disorder of glycosylation
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Glycosyltransferase
- Golgi apparatus
- Manganese
- Metal-binding
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| oligosaccharide biosynthetic process |
| protein N-linked glycosylation via asparagine |
| protein N-linked glycosylation |
| viral protein processing |
| GO Term |
|---|
| Golgi membrane |
| Golgi apparatus |
| Golgi stack |
| membrane |
| GO Term |
|---|
| alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity |
| manganese ion binding |
| protein homodimerization activity |
Sequence
MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKNEALAPPLLDAEPARGAGGRGGDHPSVAVGIRRVSNVSAASLVPAVPQPEADNLTLRYRSLVYQLNFDQTLRNVDKAGTWAPRELVLVVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVFFPFSIQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRSFYGMADKVDVKTWKSTEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPKFWKVLVPQIPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYMFPETLTISEKFTVVAISPPRKNGGWGDIRDHELCKSYRRLQ
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 54 |
|
|||
| 59 |
|
|||
| 69 | N-linked (GlcNAc...) asparagine |
|
||
| 74 |
|
|||
| 86 | N-linked (GlcNAc...) asparagine | |||
| 385 |
|
|||
| 389 |
|
|||
| 390 |
|
G57321FI
G49108TO
G43417UB
G41891LD
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective MGAT2 causes CDG-2a | Homo sapiens |
| Maturation of spike protein | Homo sapiens |
| Reactions specific to the complex N-glycan synthesis pathway | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0070253 | congenital disorder of glycosylation type IIa |
