Submissions
GlyTouCan
Glycan Structure Repository
GlyComb
Glycoconjugate Repository
GlycoPOST
Glycomics MS raw data Repository
UniCarb-DR
Glycomics MS Repository for glycan annotations from GlycoWorkbench
All Resources
Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Summary
- UniProt ID
- Q10469
- Gene Symbol
-
- MGAT2
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q10469
- PubChem
- Q10469
- The Human Metabolome Database
- HMDBP01609
- The O-GlcNAc Database
- Q10469
- O-GlcNAcAtlas
- Q10469
Annotation
- Keyword
-
- 3D-structure
- Congenital disorder of glycosylation
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Glycosyltransferase
- Golgi apparatus
- Manganese
- Metal-binding
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| protein N-linked glycosylation via asparagine |
| viral protein processing |
| protein N-linked glycosylation |
| oligosaccharide biosynthetic process |
| GO Term |
|---|
| Golgi membrane |
| Golgi apparatus |
| membrane |
| Golgi stack |
| GO Term |
|---|
| manganese ion binding |
| protein homodimerization activity |
| alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity |
Sequence
MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKNEALAPPLLDAEPARGAGGRGGDHPSVAVGIRRVSNVSAASLVPAVPQPEADNLTLRYRSLVYQLNFDQTLRNVDKAGTWAPRELVLVVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVFFPFSIQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRSFYGMADKVDVKTWKSTEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPKFWKVLVPQIPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYMFPETLTISEKFTVVAISPPRKNGGWGDIRDHELCKSYRRLQ
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 54 |
|
|||
| 59 |
|
|||
| 69 | N-linked (GlcNAc...) asparagine |
|
||
| 74 |
|
|||
| 86 | N-linked (GlcNAc...) asparagine | |||
| 385 |
|
|||
| 389 |
|
|||
| 390 |
|
G57321FI
G49108TO
G43417UB
G41891LD
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective MGAT2 causes CDG-2a | Homo sapiens |
| Maturation of spike protein | Homo sapiens |
| Reactions specific to the complex N-glycan synthesis pathway | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0014667 | disease of metabolism | |
| DOID:0050571 | congenital disorder of glycosylation type II | |
| DOID:0060823 | syndromic X-linked intellectual disability 94 | |
| DOID:0070194 | autosomal recessive chronic granulomatous disease 3 | |
| DOID:0070253 | congenital disorder of glycosylation type IIa | |
| DOID:0111401 | congenital dyserythropoietic anemia type II | |
| DOID:10003 | sensorineural hearing loss | |
| DOID:10907 | microcephaly | |
| DOID:11714 | gestational diabetes | |
| DOID:11832 | visual epilepsy |
