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alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Summary

Gene Symbol

MGAT2

Aliases

GNT-II

Organism

Homo sapiens (human)

External Links

NCBI Gene

4247

GGDB ID

gg126

HGNC

7045

mRNA

NM_002408

map

14q21

Protein

NP_002399

OMIM

602616

KEGG Gene ID

hsa:4247

PubChem

4247

Alliance of Genome Resources

HGNC:7045

Annotation

Keyword

3D-structure
Congenital disorder of glycosylation
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q10469	Beta-1,2-N-acetylglucosaminyltransferase II GlcNAc-T II Mannoside acetylglucosaminyltransferase 2 N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
oligosaccharide biosynthetic process	IEA
protein N-linked glycosylation via asparagine	IDA IMP	29666272 7635144 8808595
protein N-linked glycosylation	IBA
viral protein processing	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

viral process [inference]

viral protein processing

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	HDA	19946888
Golgi apparatus	IDA
Golgi stack	IEA
Golgi membrane	IBA IDA TAS	20378551

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
manganese ion binding	IDA	29666272
alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	IBA IDA IMP TAS	29666272 7635144 8808595
protein homodimerization activity	IDA	20378551

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-1 6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
metal ion binding
oligosaccharide biosynthetic process
protein N-linked glycosylation
transferase activity

Displaying **all 2** entries
InterPro
N-acetylglucosaminyltransferase II
Nucleotide-diphospho-sugar transferases

Human Protein Atlas

ENSG00000168282

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg126

Gene Symbol

MGAT2

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G61751GZ	Asn-Xaa	G39213VZ	Asn-Xaa	7635144

Displaying **all 3** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G61751GZ	Asn-Xaa	G39213VZ	Asn-Xaa	7635144
UDP-GlcNAc	G64272SY		G48524PJ		7635144
UDP-GlcNAc	G07483YN	Asn-Xaa	G80858MF	Asn-Xaa	7635144

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Drosophila melanogaster	NP_651763	NM_143506
Rattus norvegicus	NP_446056	NM_053604
Caenorhabditis elegans	NP_505864	NM_073463
Mus musculus	NP_666147	NM_146035

KEGG BRITE Database

Orthology

K00736

Name

alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [EC:2.4.1.143]

References

2952645

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05985	2.4.1.143	G61751GZ	G39213VZ

Rhea

RHEA:12941

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.143

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070253	congenital disorder of glycosylation type IIa	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **31 - 40** of 98 in total

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HPO ID	HPO Term
HP:0000718	Aggressive behavior
HP:0000733	Motor stereotypy
HP:0000742	Self-mutilation
HP:0000767	Pectus excavatum
HP:0000818	Abnormality of the endocrine system
HP:0000938	Osteopenia
HP:0001007	Hirsutism
HP:0001156	Brachydactyly
HP:0001250	Seizure
HP:0001252	Hypotonia

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:79329	MGAT2-congenital disorder of glycosylation
OMIM:212066	MGAT2-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

MGAT2-congenital disorder of glycosylation

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIa; CDG2A

KEGG Diseases

Congenital disorders of glycosylation type II

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **51 - 60** of 64 in total

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Species	Gene ID	Orthologous MAtrix
Phascolarctos cinereus	110220681	PHACI01683
Vulpes vulpes	112921461	VULVU14328
Electrophorus electricus	113569808	ELEEL05873
Bos indicus x Bos taurus	113900176	BOBOX22828
Podarcis muralis	114591718	PODMU06479
Salmo trutta	115169272	SALTR24436
Salmo trutta	115174519	SALTR53395
Salarias fasciatus	115401979	SALFA05767
Strigops habroptila	115606694	STRHB09369
Corvus moneduloides	116446130	CORMO23538

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements