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Nicastrin

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

42964

PubChem

42964

Alliance of Genome Resources

FB:FBgn0039234

Annotation

Keyword

Glycoprotein
Notch signaling pathway
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A0B4KHG2
E1JIV8
Q9VC27
Q7KS07

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
membrane protein ectodomain proteolysis	IDA	20421416
membrane protein ectodomain proteolysis	IMP	11781576
Notch signaling pathway	IMP	11781576 11782315 11782316 12110170 16145661 29195077
Notch signaling pathway	IGI	20421416
Notch receptor processing	IMP	11781576 11782315 11782316

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of neuron differentiation [inference]

regulation of photoreceptor cell differentiation [inference]

regulation of eye photoreceptor cell development [inference]

regulation of compound eye photoreceptor development

regulation of cell development [inference]

regulation of eye photoreceptor cell development [inference]

regulation of compound eye photoreceptor development

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell differentiation [inference]

regulation of neuron differentiation [inference]

regulation of photoreceptor cell differentiation [inference]

regulation of eye photoreceptor cell development [inference]

regulation of compound eye photoreceptor development

regulation of cell development [inference]

regulation of eye photoreceptor cell development [inference]

regulation of compound eye photoreceptor development

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
late endosome	IDA	20421416
plasma membrane	IBA
plasma membrane	HDA	19317464
membrane	IEA
recycling endosome	IDA	20421416

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

gamma-secretase complex

catalytic complex [inference]

gamma-secretase complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Nicastrin

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
Notch receptor processing

Displaying **all 2** entries
InterPro
Nicastrin, small lobe
Nicastrin

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
recycling endosome	PMID:20421416
membrane	FB:FBrf0231198
cytoplasm	FB:FBrf0219073
gamma-secretase complex	PMID:12660785
plasma membrane	PMID:19317464
late endosome	PMID:20421416

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	23385	Xenbase:XB-GENE-955077
Xenopus tropicalis	42964	Xenbase:XB-GENE-955077
Xenopus tropicalis	59287	Xenbase:XB-GENE-955077
Xenopus tropicalis	172905	Xenbase:XB-GENE-955077
Xenopus tropicalis	289231	Xenbase:XB-GENE-955077

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements