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Nicastrin

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

42964

PubChem

42964

Alliance of Genome Resources

FB:FBgn0039234

Annotation

Keyword

Glycoprotein
Notch signaling pathway
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A0B4KHG2
E1JIV8
Q9VC27
Q7KS07

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 14** of 14 in total

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GO Term	Evidence Code	PMID
amyloid-beta formation	IMP	12110170
Notch receptor processing, ligand-dependent	IGI	20421416
regulation of compound eye photoreceptor development	IMP	16145661
lateral inhibition	IMP	11782315 16145661

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of neuron differentiation [inference]

regulation of photoreceptor cell differentiation [inference]

regulation of eye photoreceptor cell development [inference]

regulation of compound eye photoreceptor development

regulation of cell development [inference]

regulation of eye photoreceptor cell development [inference]

regulation of compound eye photoreceptor development

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell differentiation [inference]

regulation of neuron differentiation [inference]

regulation of photoreceptor cell differentiation [inference]

regulation of eye photoreceptor cell development [inference]

regulation of compound eye photoreceptor development

regulation of cell development [inference]

regulation of eye photoreceptor cell development [inference]

regulation of compound eye photoreceptor development

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
late endosome	IDA	20421416
plasma membrane	IBA
plasma membrane	HDA	19317464
membrane	IEA
recycling endosome	IDA	20421416

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

gamma-secretase complex

catalytic complex [inference]

gamma-secretase complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Nicastrin

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
Notch receptor processing

Displaying **all 2** entries
InterPro
Nicastrin, small lobe
Nicastrin

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
recycling endosome	PMID:20421416
membrane	FB:FBrf0231198
cytoplasm	FB:FBrf0219073
gamma-secretase complex	PMID:12660785
plasma membrane	PMID:19317464
late endosome	PMID:20421416

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	23385	Xenbase:XB-GENE-955077
Xenopus tropicalis	42964	Xenbase:XB-GENE-955077
Xenopus tropicalis	59287	Xenbase:XB-GENE-955077
Xenopus tropicalis	172905	Xenbase:XB-GENE-955077
Xenopus tropicalis	289231	Xenbase:XB-GENE-955077

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements