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neuregulin 2

Summary

Gene Symbol

Nrg2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

432361

PubChem

432361

Alliance of Genome Resources

RGD:1303302

Annotation

Keyword

Alternative splicing
Cell membrane
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Immunoglobulin domain
Reference proteome
Secreted
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O35569

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
animal organ development	IBA
ERBB4-ERBB4 signaling pathway	ISO
cell surface receptor signaling pathway	ISO
regulation of synapse maturation	IDA IMP	26674872
nervous system development	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

ERBB2 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB3 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB4 signaling pathway

ERBB4-ERBB4 signaling pathway

intracellular signal transduction

developmental process [inference]

anatomical structure development [inference]

animal organ development

system development [inference]

nervous system development

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of synapse maturation

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

ERBB2 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB3 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB4 signaling pathway

ERBB4-ERBB4 signaling pathway

intracellular signal transduction

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
GABA-ergic synapse	IDA IMP	26674872

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction [inference]

synapse [inference]

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
growth factor activity	IEA
ErbB-3 class receptor binding	IDA	9348101

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

binding [inference]

protein binding [inference]

signaling receptor binding

ErbB-3 class receptor binding

receptor ligand activity

growth factor activity

growth factor receptor binding [inference]

epidermal growth factor receptor binding

ErbB-4 class receptor binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

pro-neuregulin-2, membrane-bound isoform

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
animal organ development
growth factor activity
nervous system development
signaling receptor binding

Displaying **all 3** entries
InterPro
Immunoglobulin I-set
Immunoglobulin-like domain
Neuregulin, C-terminal

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9542		HGNC:7998	HUMAN81145
Drosophila melanogaster	38657		FB:FBgn0003984
Canis lupus familiaris	487158			CANLF06621
Macaca mulatta	694995			MACMU39462
Bos taurus	783452			BOVIN33555
Danio rerio	100006951		ZFIN:ZDB-GENE-070615-10	DANRE20736
Mus musculus	100042150	10090_1:0050b9	MGI:1098246	MOUSE23713
Taeniopygia guttata	100219062			TAEGU04602
Danio rerio	100270726		ZFIN:ZDB-GENE-090205-2
Callithrix jacchus	100391893			CALJA27195