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neuregulin 2

Summary

Gene Symbol

Nrg2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

432361

PubChem

432361

Alliance of Genome Resources

RGD:1303302

Annotation

Keyword

Alternative splicing
Cell membrane
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Immunoglobulin domain
Reference proteome
Secreted
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O35569

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
animal organ development	IBA
ERBB4-ERBB4 signaling pathway	ISO
cell surface receptor signaling pathway	ISO
regulation of synapse maturation	IDA IMP	26674872
nervous system development	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

ERBB2 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB3 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB4 signaling pathway

ERBB4-ERBB4 signaling pathway

intracellular signal transduction

developmental process [inference]

anatomical structure development [inference]

animal organ development

system development [inference]

nervous system development

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of synapse maturation

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

ERBB2 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB3 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB4 signaling pathway

ERBB4-ERBB4 signaling pathway

intracellular signal transduction

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

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GO Term	Evidence Code	PMID
membrane	IEA
plasma membrane	IEA
extracellular region	IEA
extracellular space	IBA IDA ISO	12466964
glutamatergic synapse	IDA IMP	26674872

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction [inference]

synapse [inference]

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GO Term	Evidence Code	PMID
ErbB-4 class receptor binding	IDA	24218551
signaling receptor binding	IBA
epidermal growth factor receptor activity	IDA	9348101
epidermal growth factor receptor binding	IDA	9348101
receptor ligand activity	IDA ISO	12466964

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

binding [inference]

protein binding [inference]

signaling receptor binding

ErbB-3 class receptor binding

receptor ligand activity

growth factor activity

growth factor receptor binding [inference]

epidermal growth factor receptor binding

ErbB-4 class receptor binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

pro-neuregulin-2, membrane-bound isoform

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
animal organ development
growth factor activity
nervous system development
signaling receptor binding

Displaying **all 3** entries
InterPro
Immunoglobulin I-set
Immunoglobulin-like domain
Neuregulin, C-terminal

Ortholog

Displaying entries **31 - 40** of 83 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Fukomys damarensis	104855132	885580_0:0003aa
Pteropus vampyrus	105306960		PTEVA15843
Mandrillus leucophaeus	105551844		MANLE27596
Cercocebus atys	105599874		CERAT07538
Aotus nancymaae	105715564		AOTNA00379
Propithecus coquereli	105812005		PROCO21502
Dipodomys ordii	105988639	10020_0:00232a
Marmota marmota marmota	107151312	9994_0:0022fc
Sinocyclocheilus grahami	107557058		SINGR47883
Sinocyclocheilus grahami	107560662		SINGR77870