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NPC1 like intracellular cholesterol transporter 1

Summary

Gene Symbol

Npc1l1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

432367

PubChem

432367

Alliance of Genome Resources

RGD:1303135

Annotation

Keyword

3D-structure
Cell membrane
Cholesterol metabolism
Disulfide bond
Glycoprotein
Reference proteome
Signal
Transmembrane helix
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6IKS2
Q6T3U3	Niemann-Pick C1-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 12** of 12 in total

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GO Term	Evidence Code	PMID
lipoprotein metabolic process	ISO
vitamin E metabolic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

lipoprotein metabolic process

biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cellular metabolic process [inference]

heterocycle metabolic process [inference]

vitamin E metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

protein metabolic process [inference]

lipoprotein metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

vitamin metabolic process [inference]

fat-soluble vitamin metabolic process [inference]

vitamin E metabolic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

lipoprotein metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

vitamin E metabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

lipoprotein metabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

vitamin E metabolic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

heterocycle metabolic process [inference]

vitamin E metabolic process

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to stress [inference]

response to sterol depletion [inference]

cellular response to sterol depletion

cellular response to stress [inference]

cellular response to sterol depletion

response to activity [inference]

response to muscle activity

response to chemical [inference]

response to xenobiotic stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion

localization [inference]

establishment of localization [inference]

transport [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

vitamin transport

organic substance transport [inference]

lipid transport [inference]

sterol transport

cholesterol transport

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic hydroxy compound transport [inference]

sterol transport

cholesterol transport

Displaying **all 3** entries
GO Term	Evidence Code	PMID
apical plasma membrane	IDA	17135346
plasma membrane	IBA ISO
brush border membrane	IDA	15777641

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
vitamin E binding	ISO
heterocyclic compound binding	IPI	15928087
small GTPase binding	ISO
lipid transporter activity	IEA
cholesterol binding	IBA ISO

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

myosin binding [inference]

myosin V binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

vitamin binding [inference]

vitamin E binding

alcohol binding [inference]

cholesterol binding

heterocyclic compound binding

vitamin E binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

vitamin E binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

NPC1-like intracellular cholesterol transporter 1

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair

Displaying **all 5** entries
Gene Ontology
cholesterol binding
cholesterol transport
intestinal cholesterol absorption
lipid transporter activity
sterol transport

Displaying **all 3** entries
InterPro
Niemann-Pick C1, N-terminal
Protein patched/dispatched
Sterol-sensing domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
brush border membrane	PMID:15777641

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070113	Niemann-Pick disease type C1	Alliance of Genome Resources
DOID:14504	Niemann-Pick disease	Alliance of Genome Resources

Ortholog

Displaying entries **91 - 100** of **121** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Bos indicus x Bos taurus	113891336			BOBOX16982
Vombatus ursinus	114035543			VOMUR11210
Marmota flaviventris	114095214	93162_0:002965
Grammomys surdaster	114630182	491861_0:000319
Peromyscus leucopus	114694097	10041_0:00270a
Salmo trutta	115164219			SALTR59461
Gadus morhua	115553532			GADMO03482
Sparus aurata	115582363			SPAAU13493
Mastomys coucha	116068900	35658_0:003285
Rattus rattus	116912753	10117_0:004001

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024