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cleavage and polyadenylation specific factor 6

Summary

Gene Symbol

Cpsf6

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

432508

PubChem

432508

Alliance of Genome Resources

MGI:1913948

Annotation

Keyword

Cytoplasm
Methylation
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
mRNA processing

Proteins

Displaying **all 3** entries
UniProt	Protein Name
H3BJW3
H3BJ30
Q6NVF9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
mRNA processing	ISO
mRNA 3'-end processing	ISO
positive regulation of RNA export from nucleus	ISS
positive regulation of RNA export from nucleus	ISO
protein tetramerization	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization

protein heterotetramerization

protein heterooligomerization [inference]

protein heterotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization

protein heterotetramerization

protein heterooligomerization [inference]

protein heterotetramerization

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of nucleobase-containing compound transport [inference]

positive regulation of nucleobase-containing compound transport [inference]

positive regulation of RNA export from nucleus

regulation of RNA export from nucleus [inference]

positive regulation of RNA export from nucleus

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of nucleocytoplasmic transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of RNA export from nucleus [inference]

positive regulation of RNA export from nucleus

positive regulation of transport [inference]

positive regulation of nucleobase-containing compound transport [inference]

positive regulation of RNA export from nucleus

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of nucleocytoplasmic transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of RNA export from nucleus [inference]

positive regulation of RNA export from nucleus

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

positive regulation of transport [inference]

positive regulation of nucleobase-containing compound transport [inference]

positive regulation of RNA export from nucleus

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of nucleocytoplasmic transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of RNA export from nucleus [inference]

positive regulation of RNA export from nucleus

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	ISO
nucleus	IDA	18032416
nucleoplasm	ISS
nucleoplasm	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

mRNA cleavage factor complex

mRNA cleavage and polyadenylation specificity factor complex

ribonucleoprotein complex

cellular anatomical entity [inference]

nuclear body [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
RNA binding	ISO
mRNA binding	ISS
mRNA binding	ISO
mRNA binding	IBA
protein binding	IPI	29799838

GO Hierarchy

molecular function

binding [inference]

protein binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding [inference]

ribosomal large subunit binding

exon-exon junction complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

mRNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cleavage and polyadenylation specificity factor subunit

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
mRNA alternative polyadenylation

Displaying **all 5** entries
InterPro
CPSF6/7 family
Cleavage and polyadenylation specificity factor subunit 6, RNA recognition motif
Nucleotide-binding alpha-beta plait domain superfamily
RNA recognition motif domain
RNA-binding domain superfamily

Ortholog

Displaying entries **11 - 20** of 78 in total

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Species	Gene ID	Orthologous MAtrix
Ornithorhynchus anatinus	100080829	ORNAN06219
Sus scrofa	100152191	PIGXX25797
Pongo abelii	100174771	PONAB05044
Callithrix jacchus	100393328	CALJA44219
Ailuropoda melanoleuca	100482011	AILME09774
Nomascus leucogenys	100589466	NOMLE01527
Loxodonta africana	100666041	LOXAF19662
Oreochromis niloticus	100697945	ORENI24075
Cavia porcellus	100732506	CAVPO05609
Cricetulus griseus	100773290	CRIGR02982