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Serrate

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

43275

PubChem

43275

Alliance of Genome Resources

FB:FBgn0004197

Annotation

Keyword

3D-structure
Developmental protein
Differentiation
Disulfide bond
EGF-like domain
Glycoprotein
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0B4LIS1
P18168	Protein beaded

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
cell communication	IEA
lateral inhibition	IMP	16093323
cuticle pattern formation	IMP	16125166
larval salivary gland morphogenesis	IMP	12798300
germ-line stem cell population maintenance	IGI	17070683

GO Hierarchy

biological process

immune system process [inference]

hemocyte differentiation [inference]

crystal cell differentiation

cellular process [inference]

cell cycle [inference]

mitotic cell cycle [inference]

second mitotic wave involved in compound eye morphogenesis

cell communication

cell-cell signaling [inference]

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cell population proliferation [inference]

glial cell proliferation

cellular developmental process [inference]

cell differentiation [inference]

hemocyte differentiation [inference]

crystal cell differentiation

cell development [inference]

hemopoiesis [inference]

post-embryonic hemopoiesis [inference]

larval lymph gland hemopoiesis

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

imaginal disc pattern formation [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

wing disc pattern formation [inference]

wing disc anterior/posterior pattern formation

anterior/posterior pattern specification [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

cuticle pattern formation

segmentation [inference]

appendage segmentation [inference]

imaginal disc-derived leg segmentation

stem cell population maintenance [inference]

germ-line stem cell population maintenance

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

animal organ morphogenesis [inference]

gland morphogenesis [inference]

salivary gland morphogenesis

larval salivary gland morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

post-embryonic hemopoiesis [inference]

larval lymph gland hemopoiesis

animal organ development [inference]

sensory organ development

eye development [inference]

compound eye development

imaginal disc development [inference]

eye-antennal disc development

cellular developmental process [inference]

cell differentiation [inference]

hemocyte differentiation [inference]

crystal cell differentiation

cell development [inference]

hemopoiesis [inference]

post-embryonic hemopoiesis [inference]

larval lymph gland hemopoiesis

maintenance of cell number [inference]

stem cell population maintenance [inference]

germ-line stem cell population maintenance

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of hemocyte differentiation [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

signaling [inference]

cell-cell signaling [inference]

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of hemocyte differentiation [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of hemocyte differentiation [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of multicellular organismal process [inference]

regulation of hemocyte differentiation [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
membrane	IEA
axolemma	IDA	1840519
apical plasma membrane	IDA	17006545
plasma membrane	IDA	16643882 1840519
apical cortex	IDA	15760269

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm [inference]

cell cortex [inference]

cell cortex region [inference]

apical cortex

cytoplasmic region [inference]

cell cortex region [inference]

apical cortex

cell surface

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

neuron projection membrane [inference]

axolemma

leading edge membrane [inference]

neuron projection membrane [inference]

axolemma

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15829515
glycosphingolipid binding	IDA	20176925
receptor ligand activity	IDA	20203305
Notch binding	IBA IDA IEA IPI	10504334 12909620 17923477 20203305
calcium ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

lipid binding [inference]

sphingolipid binding [inference]

glycosphingolipid binding

glycolipid binding [inference]

glycosphingolipid binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycolipid binding [inference]

glycosphingolipid binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Notch

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 4** entries
InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
apical plasma membrane	PMID:17006545
apical cortex	PMID:15760269
plasma membrane	PMID:16643882 PMID:1840519
cell surface	PMID:20203305
axolemma	PMID:1840519

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:0110274	autosomal recessive limb-girdle muscular dystrophy	Alliance of Genome Resources
DOID:10595	Charcot-Marie-Tooth disease	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:13375	temporal arteritis	Alliance of Genome Resources
DOID:1682	congenital heart disease	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources
DOID:3770	pulmonary fibrosis	Alliance of Genome Resources
DOID:6419	tetralogy of Fallot	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:8398	osteoarthritis	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 49 in total

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Species	Gene ID	OrthoDB
Drosophila ananassae	6505593	7217_1:000674
Drosophila yakuba	6538294	7245_0:000cb5
Drosophila erecta	6554646	7220_1:0006bb
Drosophila grimshawi	6567383	7222_1:001518
Drosophila mojavensis	6574880	7230_1:001380
Drosophila persimilis	6587390	7234_1:000b2d
Drosophila sechellia	6617149	7238_1:0027bd
Drosophila virilis	6630619	7244_1:00032f
Drosophila willistoni	6647176	7260_0:002178
Drosophila simulans	6729833	7240_1:002176