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acetylcholinesterase (Yt blood group)

Summary

Gene Symbol

ACHE

Aliases

Yt blood group

Organism

Homo sapiens (human)

External Links

NCBI Gene

HGNC

108

KEGG Gene ID

hsa:43

PubChem

Alliance of Genome Resources

HGNC:108

Annotation

Keyword

3D-structure
Alternative splicing
Blood group antigen
Cell membrane
Direct protein sequencing
Disulfide bond
GPI-anchor
Neurotransmitter degradation
Nucleus
Reference proteome
Secreted
Serine esterase
Signal
Synapse

Proteins

Displaying 1 entry
UniProt	Protein Name
P22303

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
retina development in camera-type eye	IEA
acetylcholine catabolic process in synaptic cleft		1517212
regulation of receptor recycling	IEA
positive regulation of protein secretion		11283752
amyloid precursor protein metabolic process		12769797

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

protein metabolic process [inference]

amyloid precursor protein metabolic process

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

catabolic process [inference]

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

primary metabolic process [inference]

protein metabolic process [inference]

amyloid precursor protein metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

amyloid precursor protein metabolic process

acetate ester metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

organonitrogen compound metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

protein metabolic process [inference]

amyloid precursor protein metabolic process

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

cellular process [inference]

cell adhesion

signal transduction [inference]

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cellular developmental process [inference]

cell development [inference]

osteoblast development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

osteoblast development

system development [inference]

nervous system development

retina development in camera-type eye

cellular developmental process [inference]

cell development [inference]

osteoblast development

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of signaling [inference]

regulation of receptor recycling

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic [inference]

negative regulation of synaptic transmission, cholinergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

regulation of cellular process [inference]

signal transduction [inference]

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic [inference]

negative regulation of synaptic transmission, cholinergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

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GO Term	Evidence Code	PMID
nucleus	IEA
neuromuscular junction	IEA
extracellular region	IDA TAS	11283752 1517212
basement membrane		16289501
synaptic cleft	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

synaptic cleft

membrane

plasma membrane

cell junction [inference]

synapse

neuromuscular junction

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix [inference]

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

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GO Term	Evidence Code	PMID
collagen binding	IDA	12524166
protein binding	IPI	10800960 15526038 18194455
acetylcholinesterase activity	IBA IDA IMP TAS	1517212
cholinesterase activity	IDA	1517212
serine hydrolase activity	IDA	3954986

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

cholinesterase activity

acetylcholinesterase activity

serine hydrolase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

laminin binding

protein dimerization activity [inference]

protein homodimerization activity

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

ion binding [inference]

cation binding [inference]

acetylcholine binding

protein-containing complex binding [inference]

collagen binding

extracellular matrix binding [inference]

laminin binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K01049

Name

acetylcholinesterase [EC:3.1.1.7]

References

Rhea

RHEA:17561

acetylcholine + H₂O

choline + H⁺ + acetate

Enzyme

3.1.1.7

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	DisGeNET
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050161	lower respiratory tract disease	DisGeNET
DOID:0050214	Lambert-Eaton myasthenic syndrome	DisGeNET
DOID:0050328	congenital hypothyroidism	DisGeNET DisGeNET DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0050458	juvenile myelomonocytic leukemia	DisGeNET
DOID:0050526	Gamstorp-Wohlfart syndrome	DisGeNET
DOID:0050557	congenital muscular dystrophy	DisGeNET
DOID:0050588	muscular dystrophy-dystroglycanopathy type B1	DisGeNET

PubChem Disease

MedGen Diseases

Antigen in Cartwright blood group system

OMIM Phenotypes

YT BLOOD GROUP ANTIGEN

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001073
Gene Name: acetylcholinesterase (Yt blood group)

Ortholog

Displaying entries **31 - 40** of 75 in total

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Species	Gene ID	Orthologous MAtrix
Pan troglodytes	100609296	PANTR40998
Pongo abelii	100939726	PONAB33819
Canis lupus familiaris	489828	CANLF16192
Vulpes vulpes	112935693	VULVU32108
Ursus americanus	123777339	URSAM13475
Mustela putorius furo	101683197	MUSPF09528
Felis catus	493674	FELCA35129
Panthera leo	122210190	PANLE28343
Balaenoptera musculus	118881962	BALMU21692
Loxodonta africana	100674399	LOXAF01455

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Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements