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angiotensin I converting enzyme

Summary

Gene Symbol

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 449567
KEGG Gene ID: ptr:449567
PubChem: 449567

Annotation

Keyword

Alternative promoter usage
Calmodulin-binding
Carboxypeptidase
Cell membrane
Cytoplasm
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
H2QZH0
Q9GLN7	Dipeptidyl carboxypeptidase I Kininase II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 27 in total

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GO Term	Evidence Code	PMID
regulation of heart rate by cardiac conduction
male gonad development
angiotensin maturation
regulation of angiotensin metabolic process
positive regulation of peptidyl-cysteine S-nitrosylation

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

myeloid leukocyte mediated immunity [inference]

neutrophil mediated immunity

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta metabolic process

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

catabolic process [inference]

hormone catabolic process

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

hormone metabolic process

peptide hormone processing [inference]

angiotensin maturation

hormone catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta metabolic process

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

angiotensin-activated signaling pathway

cell population proliferation [inference]

cell proliferation in bone marrow

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

reproductive structure development [inference]

gonad development [inference]

male gonad development

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

heart process [inference]

heart contraction

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure development [inference]

animal organ development [inference]

kidney development

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

icosanoid secretion [inference]

arachidonic acid secretion

organic substance transport [inference]

lipid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

icosanoid transport [inference]

icosanoid secretion [inference]

arachidonic acid secretion

arachidonate transport [inference]

arachidonic acid secretion

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

icosanoid transport [inference]

icosanoid secretion [inference]

arachidonic acid secretion

arachidonate transport [inference]

arachidonic acid secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of peptidyl-cysteine S-nitrosylation [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of angiotensin metabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of peptidyl-cysteine S-nitrosylation [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of angiotensin metabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of peptidyl-cysteine S-nitrosylation [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of angiotensin metabolic process

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

angiotensin-activated signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cell population proliferation [inference]

regulation of stem cell proliferation [inference]

regulation of hematopoietic stem cell proliferation

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of gap junction assembly [inference]

negative regulation of gap junction assembly

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of cell junction assembly [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of gap junction assembly [inference]

negative regulation of gap junction assembly

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of blood pressure

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin

positive regulation of blood pressure [inference]

positive regulation of systemic arterial blood pressure

regulation of hormone levels [inference]

hormone metabolic process

peptide hormone processing [inference]

angiotensin maturation

hormone catabolic process

regulation of synaptic plasticity

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GO Term	Evidence Code	PMID
external side of plasma membrane
plasma membrane	IEA	30032202
endosome
extracellular region
lysosome

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
tripeptidyl-peptidase activity
metal ion binding
bradykinin receptor binding
metalloendopeptidase activity
metallopeptidase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

metallopeptidase activity

metalloendopeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

peptidyl-dipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

metallopeptidase activity

metalloendopeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

peptidyl-dipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

bradykinin receptor binding

calmodulin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

ion binding [inference]

anion binding [inference]

chloride ion binding

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

angiotensin-converting enzyme isoform 1 precursor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying entries **11 - 20** of 39 in total

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Gene Ontology
hormone catabolic process
hydrolase activity
kidney development
male gonad development
metal ion binding
metallodipeptidase activity
metalloendopeptidase activity
metallopeptidase activity
mitogen-activated protein kinase binding
mitogen-activated protein kinase kinase binding

Displaying 1 entry
InterPro
Peptidase M2, peptidyl-dipeptidase A

KEGG BRITE Database

Orthology

K01283

Name

peptidyl-dipeptidase A [EC:3.4.15.1]

References

Rhea

RHEA:63560

angiotensin I + H₂O

L-histidyl-L-leucine + angiotensin II

Enzyme

3.4.15.1

PMID

10969042

Ortholog

Displaying entries **1 - 10** of 24 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	1636	9606_0:0016f2
Equus caballus	100064801		HORSE04640
Pongo abelii	100453403	9601_0:004392
Nomascus leucogenys	100592115		NOMLE16246
Pan paniscus	100980711	9597_0:00435d	PANPA17686
Saimiri boliviensis boliviensis	101052117		SAIBB36499
Gorilla gorilla gorilla	101145787	9595_0:001bfc
Heterocephalus glaber	101701835		HETGA12181
Chinchilla lanigera	102027972		CHILA17794
Macaca fascicularis	102128376		MACFA14505

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements