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ST6 beta-galactoside alpha-2,6-sialyltransferase 2

Summary

Gene Symbol

ST6GAL2

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 450198
KEGG Gene ID: ptr:450198
PubChem: 450198

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A2J8J6X7	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2 ST6Gal II Sialyltransferase 2
A0A6D2VSW5	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2 ST6Gal II Sialyltransferase 2
Q701R4	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2 ST6Gal II Sialyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA	22301074
protein glycosylation	IEA	22301074
oligosaccharide metabolic process
sialylation	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

primary metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

sialylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IEA	30032202
Golgi cisterna membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying 1 entry
GO Term	Evidence Code	PMID
beta-galactoside alpha-2,6-sialyltransferase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity [inference]

beta-galactoside alpha-2,6-sialyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beta-galactoside alpha-2,6-sialyltransferase

Functional Category

H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
beta-galactoside alpha-2,6-sialyltransferase activity
sialylation
sialyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
GT29-like superfamiliy
Glycosyl transferase family 29

KEGG BRITE Database

Orthology

K00779

Name

beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2) [EC:2.4.3.1]

References

12235148

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R06188	2.4.3.1	G51331BY	G09376MR

Rhea

RHEA:21552

a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + CMP-N-acetyl-β-neuraminate

H⁺ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide + CMP

Enzyme

2.4.3.1

PMID

2460092

RHEA:52104

a β-D-galactoside + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl derivative + H⁺ + CMP

Enzyme

2.4.3.1

PMID

RHEA:11836

N-acetyl-β-lactosamine + CMP-N-acetyl-β-neuraminate

H⁺ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosamine + CMP

Enzyme

2.4.3.1

PMID

Ortholog

Displaying entries **11 - 20** of 65 in total

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Species	Gene ID	Orthologous MAtrix
Oryctolagus cuniculus	100358153	RABIT08271
Callithrix jacchus	100411939	CALJA09865
Pongo abelii	100456090	PONAB22626
Ailuropoda melanoleuca	100478457	AILME18571
Sus scrofa	100512775	PIGXX21477
Anolis carolinensis	100529108	ANOCA04597
Meleagris gallopavo	100545097	MELGA01544
Nomascus leucogenys	100580010	NOMLE08911
Loxodonta africana	100660981	LOXAF10867
Cricetulus griseus	100763756	CRIGR06212

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OrthoDB (Group)

KEGG BRITE Database

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Acknowledgements