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CF transmembrane conductance regulator

Summary

Gene Symbol

CFTR

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 463674
PubChem: 463674

Annotation

Keyword

ATP-binding
Cell membrane
Chloride channel
Endoplasmic reticulum
Endosome
Glycoprotein
Isomerase
Isopeptide bond
Nucleus
Palmitate
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q2QLE5	ATP-binding cassette sub-family C member 7 Channel conductance-controlling ATPase cAMP-dependent chloride channel
A0A2J8QXD7	ATP-binding cassette sub-family C member 7 Channel conductance-controlling ATPase cAMP-dependent chloride channel

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
bicarbonate transport	IEA	30032202
response to endoplasmic reticulum stress
transepithelial water transport
sperm capacitation
multicellular organismal-level water homeostasis

GO Hierarchy

biological process

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

sperm capacitation

cellular developmental process [inference]

cell maturation [inference]

sperm capacitation

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to forskolin

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to ketone [inference]

cellular response to forskolin

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

reproductive process [inference]

developmental process involved in reproduction [inference]

sperm capacitation

cellular process involved in reproduction in multicellular organism [inference]

sperm capacitation

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

developmental process [inference]

developmental process involved in reproduction [inference]

sperm capacitation

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

sperm capacitation

cellular developmental process [inference]

cell maturation [inference]

sperm capacitation

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organic cyclic compound [inference]

response to forskolin [inference]

cellular response to forskolin

response to lipid [inference]

cellular response to lipid [inference]

cellular response to forskolin

response to forskolin [inference]

cellular response to forskolin

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to forskolin

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to alcohol [inference]

cellular response to forskolin

response to alcohol [inference]

cellular response to alcohol [inference]

cellular response to forskolin

response to forskolin [inference]

cellular response to forskolin

response to ketone [inference]

cellular response to ketone [inference]

cellular response to forskolin

response to forskolin [inference]

cellular response to forskolin

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to forskolin

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to ketone [inference]

cellular response to forskolin

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to alcohol [inference]

cellular response to alcohol [inference]

cellular response to forskolin

response to forskolin [inference]

cellular response to forskolin

response to ketone [inference]

cellular response to ketone [inference]

cellular response to forskolin

response to forskolin [inference]

cellular response to forskolin

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to ketone [inference]

cellular response to forskolin

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to forskolin

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to ketone [inference]

cellular response to forskolin

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

fluid transport [inference]

water transport [inference]

transepithelial water transport

epithelial fluid transport [inference]

transepithelial water transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transepithelial transport [inference]

epithelial fluid transport [inference]

transepithelial water transport

organic substance transport [inference]

water transport [inference]

transepithelial water transport

organic anion transport [inference]

bicarbonate transport

one-carbon compound transport [inference]

bicarbonate transport

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

regulation of biological quality [inference]

regulation of membrane potential [inference]

membrane hyperpolarization

regulation of body fluid levels [inference]

multicellular organismal-level water homeostasis

regulation of intracellular pH [inference]

intracellular pH elevation

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleus
early endosome
endoplasmic reticulum membrane
cytosol	IEA	30032202
plasma membrane	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical entity [inference]

cytosol

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

bounding membrane of organelle [inference]

endosome membrane [inference]

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
chloride channel activity	IEA	22301074
intracellularly ATP-gated chloride channel activity
ATP binding	IEA	22301074
bicarbonate transmembrane transporter activity
chloride transmembrane transporter activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

isomerase activity

transporter activity [inference]

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

bicarbonate transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellularly ATP-gated ion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

chloride transmembrane transporter activity

chloride channel activity

intracellularly ATP-gated chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity

chloride channel activity

intracellularly ATP-gated chloride channel activity

bicarbonate transmembrane transporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellularly ATP-gated ion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellularly ATP-gated ion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ATP-gated ion channel activity [inference]

intracellularly ATP-gated ion channel activity [inference]

intracellularly ATP-gated chloride channel activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

salt transmembrane transporter activity [inference]

bicarbonate transmembrane transporter activity

chloride transmembrane transporter activity

chloride channel activity

intracellularly ATP-gated chloride channel activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

chloride channel inhibitor activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

chloride channel inhibitor activity

ion channel regulator activity [inference]

ion channel inhibitor activity [inference]

chloride channel inhibitor activity

chloride channel regulator activity [inference]

chloride channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

chloride channel inhibitor activity

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

multidrug resistance-associated

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Ortholog

Displaying entries **1 - 10** of 82 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	1080	HUMAN90993
Mus musculus	12638	MOUSE49101
Rattus norvegicus	24255	RATNO29396
Bos taurus	281067	BOVIN27987
Ovis aries	443347	SHEEP15466
Canis lupus familiaris	492302	CANLF03852
Felis catus	492308	FELCA05668
Takifugu rubripes	492310	TAKRU51325
Danio rerio	559080	DANRE14528
Macaca mulatta	574346	MACMU32462

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Acknowledgements