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Guidelines

MIRAGE

phospholipase A2 group VI

Summary

Gene Symbol

PLA2G6

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 470208
KEGG Gene ID: ptr:470208
PubChem: 470208

Annotation

Keyword

ANK repeat
Hydrolase
Lipid degradation
Reference proteome
Repeat

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A6D2Y6C1
A0A6D2XX29
H2QLN4
K6ZYI9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cardiolipin acyl-chain remodeling	IEA	30032202
positive regulation of ceramide biosynthetic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular component biogenesis [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
mitochondrion	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IEA	22301074
calcium-independent phospholipase A2 activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase A2 activity [inference]

calcium-independent phospholipase A2 activity

carboxylic ester hydrolase activity [inference]

phospholipase A2 activity [inference]

calcium-independent phospholipase A2 activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

calcium-independent phospholipase A2

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
calcium-independent phospholipase A2 activity
cardiolipin acyl-chain remodeling
hydrolase activity
lipid metabolic process
positive regulation of ceramide biosynthetic process

Displaying **all 5** entries
InterPro
85/88 kDa calcium-independent phospholipase A2
Acyl transferase/acyl hydrolase/lysophospholipase
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
Patatin-like phospholipase domain

KEGG BRITE Database

Orthology

K16343

Name

calcium-independent phospholipase A2 [EC:3.1.1.4]

References

Rhea

H₂O + a 1,2-diacyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + a 1-acyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.4

PMID

H₂O + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + 1-O-alkyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.4

PMID

9442064

Ortholog

Displaying entries **1 - 10** of 73 in total

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Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8398		HUMAN60516
Mus musculus	53357		MOUSE16942
Rattus norvegicus	360426		RATNO38024
Danio rerio	406370		DANRE23128
Canis lupus familiaris	481256		CANLF01620
Bos taurus	535381		BOVIN30650
Monodelphis domestica	100016178		MONDO00647
Ornithorhynchus anatinus	100090638		ORNAN06146
Taeniopygia guttata	100222459		TAEGU09100
Callithrix jacchus	100415535		CALJA20217

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025