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5-hydroxytryptamine receptor 1A

Summary

Gene Symbol

HTR1A

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 471533
PubChem: 471533

Annotation

Keyword

Behavior
Cell membrane
Cell projection
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9N298	Serotonin receptor 1A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
regulation of dopamine metabolic process
behavioral fear response
serotonin metabolic process
regulation of behavior	IEA	22301074
regulation of vasoconstriction	IEA	22301074

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

ammonium ion metabolic process [inference]

serotonin metabolic process

organonitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

primary amino compound metabolic process [inference]

serotonin metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process

indole-containing compound metabolic process [inference]

serotonin metabolic process

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

heterocycle metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process

indole-containing compound metabolic process [inference]

serotonin metabolic process

organonitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

primary amino compound metabolic process [inference]

serotonin metabolic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process

indole-containing compound metabolic process [inference]

serotonin metabolic process

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

heterocycle metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

behavior [inference]

behavioral defense response [inference]

behavioral fear response

exploration behavior

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of amine metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of primary metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of signaling [inference]

regulation of hormone secretion

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of serotonin secretion

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

regulation of cell communication [inference]

regulation of hormone secretion

regulation of cellular metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of secretion by cell [inference]

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction

regulation of behavior

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IEA	22301074 30032202
dendrite
synapse

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

Displaying **all 5** entries
GO Term	Evidence Code	PMID
receptor-receptor interaction
neurotransmitter receptor activity
G protein-coupled serotonin receptor activity	IEA	22301074
serotonin binding
dopamine neurotransmitter receptor activity, coupled via Gs	IEA	30032202

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor-receptor interaction

ion binding [inference]

cation binding [inference]

serotonin binding

amine binding [inference]

serotonin binding

organic cyclic compound binding [inference]

serotonin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

neurotransmitter receptor activity

postsynaptic neurotransmitter receptor activity [inference]

dopamine neurotransmitter receptor activity [inference]

dopamine neurotransmitter receptor activity, coupled via Gs

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level: Hominidae
Group Name: 5-hydroxytryptamine receptor 1A

Displaying entries **1 - 10** of 17 in total

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Gene Ontology
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-inhibiting serotonin receptor signaling pathway
behavioral fear response
chemical synaptic transmission
exploration behavior
gamma-aminobutyric acid signaling pathway
neurotransmitter receptor activity
receptor-receptor interaction
regulation of behavior

Displaying **all 4** entries
InterPro
5-Hydroxytryptamine 1A receptor
5-hydroxytryptamine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	3350	9606_1:00197d	HUMAN79340
Mus musculus	15550		MOUSE11057
Rattus norvegicus	24473		RATNO25081
Bos taurus	407137		BOVIN15880
Canis lupus familiaris	487230		CANLF06728
Macaca mulatta	694991		MACMU38734
Danio rerio	100001828		DANRE43238
Oryctolagus cuniculus	100008780		RABIT02014
Monodelphis domestica	100032349		MONDO18136
Taeniopygia guttata	100227736		TAEGU32076