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Guidelines

MIRAGE

tolloid-like 1

Summary

Gene Symbol

tll1

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

474335

PubChem

474335

Alliance of Genome Resources

ZFIN:ZDB-GENE-041020-1

Annotation

Keyword

Calcium
Developmental protein
Disulfide bond
EGF-like domain
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Repeat
Signal
Zinc
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O57460	Mini fin protein
B3DJN6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
blood vessel development	IMP	10375503
mesoderm formation	IMP	10375503
endothelial cell development	IMP	10375503
proteolysis	IDA	16518392 9395394
proteolysis	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

protein processing

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein processing

protein maturation [inference]

protein processing

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development

hemopoiesis [inference]

embryonic hemopoiesis

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation

determination of ventral identity

developmental process [inference]

anatomical structure morphogenesis [inference]

appendage morphogenesis [inference]

fin morphogenesis [inference]

medial fin morphogenesis [inference]

embryonic medial fin morphogenesis [inference]

embryonic caudal fin morphogenesis

caudal fin morphogenesis [inference]

embryonic caudal fin morphogenesis

embryonic appendage morphogenesis [inference]

embryonic medial fin morphogenesis [inference]

embryonic caudal fin morphogenesis

post-anal tail morphogenesis

embryonic morphogenesis [inference]

embryonic appendage morphogenesis [inference]

embryonic medial fin morphogenesis [inference]

embryonic caudal fin morphogenesis

anatomical structure formation involved in morphogenesis [inference]

formation of primary germ layer [inference]

mesoderm formation

anatomical structure development [inference]

blood vessel development

cell development [inference]

epithelial cell development [inference]

endothelial cell development

hemopoiesis [inference]

embryonic hemopoiesis

animal organ development [inference]

embryonic organ development [inference]

embryonic hemopoiesis

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development

hemopoiesis [inference]

embryonic hemopoiesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	NAS	10375503
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity	IBA
metalloendopeptidase activity	IEA
calcium ion binding	IEA
protein binding	IPI	16518392
peptidase activity	IDA	16518392

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tolloid

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium ion binding
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 10** entries
InterPro
Bone morphogenetic protein 1/tolloid-like protein
CUB domain
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Metallopeptidase, catalytic domain superfamily
Peptidase M12A
Peptidase, metallopeptidase
Spermadhesin, CUB domain superfamily

Ortholog

Displaying entries **21 - 30** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Pongo abelii	100460238		PONAB28238
Ailuropoda melanoleuca	100473888		AILME10648
Anolis carolinensis	100567350		ANOCA15170
Nomascus leucogenys	100587003		NOMLE34526
Loxodonta africana	100674256		LOXAF08701
Oreochromis niloticus	100693538		ORENI62945
Cavia porcellus	100723059		CAVPO01057
Cricetulus griseus	100755072		CRIGR06666
Otolemur garnettii	100947195		OTOGA03013
Pan paniscus	100984472		PANPA31250

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Last updated: December 8, 2025