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sodium voltage-gated channel alpha subunit 10

Summary

Gene Symbol

SCN10A

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene: 477026
PubChem: 477026

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Reference proteome
Repeat
Sodium channel
Transmembrane helix
Ubl conjugation
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
O46669	NaNG Sodium channel protein type X subunit alpha Voltage-gated sodium channel subunit alpha Nav1.8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
membrane depolarization during action potential	IEA	30032202
regulation of heart rate	IEA	30032202
neuronal action potential	IEA	30032202
regulation of atrial cardiac muscle cell membrane depolarization	IEA	30032202
AV node cell action potential	IEA	30032202

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of membrane depolarization [inference]

regulation of atrial cardiac muscle cell membrane depolarization

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate

regulation of biological quality [inference]

regulation of heart rate

regulation of membrane potential [inference]

action potential [inference]

neuronal action potential

cardiac muscle cell action potential [inference]

AV node cell action potential

regulation of membrane depolarization [inference]

regulation of atrial cardiac muscle cell membrane depolarization

membrane depolarization [inference]

membrane depolarization during action potential

Displaying **all 3** entries
GO Term	Evidence Code	PMID
voltage-gated sodium channel complex	IEA	22301074 30032202
plasma membrane	IEA	30032202
axon	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated sodium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying **all 2** entries
GO Term	Evidence Code	PMID
voltage-gated sodium channel activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IEA	30032202

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sodium channel alpha subunit

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
membrane depolarization during action potential
monoatomic ion channel activity
monoatomic ion transport
neuronal action potential
sodium ion transmembrane transport
voltage-gated sodium channel activity

Displaying **all 3** entries
InterPro
Ion transport domain
Voltage-dependent channel domain superfamily
Voltage-gated cation channel calcium and sodium

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	6336		HUMAN69254
Mus musculus	20264		MOUSE64007
Rattus norvegicus	29571		RATNO41633
Pan troglodytes	460274		PANTR30807
Macaca mulatta	694962		MACMU29162
Equus caballus	100055493		HORSE10901
Bos taurus	100299477		BOVIN17270
Callithrix jacchus	100389973		CALJA14664
Pongo abelii	100455011		PONAB25272
Ailuropoda melanoleuca	100464617	9646_0:001b86