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farnesyl-diphosphate farnesyltransferase 1

Summary

Gene Symbol

FDFT1

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene: 477362
KEGG Gene ID: cfa:477362
PubChem: 477362

Annotation

Keyword

Multifunctional enzyme
Reference proteome
Transferase

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A8I3P8C5
A0A8C0TGW2
A0A8I3P3D2
A0A8C0NTL6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cholesterol biosynthetic process	IEA	30032202
farnesyl diphosphate metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

farnesyl diphosphate metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

farnesyl diphosphate metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

farnesyl diphosphate metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

farnesyl diphosphate metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
squalene synthase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

prenyltransferase activity [inference]

farnesyltranstransferase activity [inference]

squalene synthase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Squalene synthase

Functional Category

H: Coenzyme transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 8** entries
Gene Ontology
cholesterol biosynthetic process
ergosterol biosynthetic process
farnesyl diphosphate metabolic process
farnesyl-diphosphate farnesyltransferase activity
farnesyltranstransferase activity
lipid biosynthetic process
squalene synthase activity
transferase activity

Displaying **all 6** entries
InterPro
Isoprenoid synthase domain superfamily
Squalene synthase-like
Squalene/phytoene synthase, conserved site
Squalene/phytoene synthase
Trans-isoprenyl diphosphate synthases, eukaryotic-type
Trans-isoprenyl diphosphate synthases, head-to-head

KEGG BRITE Database

Orthology

K00801

Name

farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21]

References

Rhea

H⁺ + (2E,6E)-farnesyl diphosphate + NADH

squalene + diphosphate + NAD⁺

Enzyme

2.5.1.21

PMID

H⁺ + (2E,6E)-farnesyl diphosphate + NADPH

squalene + diphosphate + NADP⁺

Enzyme

2.5.1.21

PMID

Ortholog

Displaying entries **1 - 10** of **108** in total

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Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2222			HUMAN92501
Mus musculus	14137			MOUSE12658
Rattus norvegicus	29580			RATNO10425
Bos taurus	281767			BOVIN34136
Danio rerio	571911			DANRE20007
Macaca mulatta	696396			MACMU43211
Pan troglodytes	740684			PANTR41982
Monodelphis domestica	100029000			MONDO04025
Ornithorhynchus anatinus	100082427			ORNAN29774
Pongo abelii	100173463			PONAB34612

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024