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ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

Summary

Gene Symbol

ST8SIA1

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene: 477672
KEGG Gene ID: cfa:477672
PubChem: 477672

Annotation

Keyword

Disulfide bond
Glycoprotein
Golgi apparatus
Reference proteome
Signal-anchor
Sphingolipid metabolism
Transferase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A8C0TU42	Alpha-2,8-sialyltransferase 8A Ganglioside GD3 synthase Sialyltransferase 8A Sialyltransferase St8Sia I
A0A8I3S0P4	Alpha-2,8-sialyltransferase 8A Ganglioside GD3 synthase Sialyltransferase 8A Sialyltransferase St8Sia I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein glycosylation	IEA	22301074 30032202
oligosaccharide metabolic process	IEA	30032202
N-glycan processing	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

Displaying 1 entry
GO Term	Evidence Code	PMID
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity [inference]

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sialyltransferase

Functional Category

H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
sialyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
GT29-like superfamiliy
Glycosyl transferase family 29

KEGG BRITE Database

Orthology

K03371

Name

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A) [EC:2.4.3.8]

References

8058740

Reactions

Displaying **all 4** entries
KEGG Reaction	Enzyme	Acceptor	Product
R13175	2.4.3.8	G32254QI	G50116PC
R06032	2.4.3.8	G01767JJ	G70647TI
R05947	2.4.3.8	G98544DH	G93899SO
R05940	2.4.3.8	G91237TK	G98544DH

Rhea

RHEA:19313

an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl derivative + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl derivative + H⁺ + CMP

Enzyme

2.4.3.8

PMID

Ortholog

Displaying entries **91 - 100** of **113** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Mirounga leonina	118025582	9715_0:003432
Callithrix jacchus	118144189		CALJA46527
Scophthalmus maximus	118287693		SCOMX21224
Halichoerus grypus	118552652	9711_0:002551
Balaenoptera musculus	118902638		BALMU03311
Hyaena hyaena	120236008	95912_0:001c7b
Puma yagouaroundi	121038820	1608482_0:001d92
Vulpes lagopus	121480215	494514_0:0048de
Panthera leo	122224343	9689_0:001de6	PANLE17723
Prionailurus bengalensis	122473547	37029_0:0044e8

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements