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ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

Summary

Gene Symbol

ATP2A2

Organism

Homo sapiens (human)

External Links

NCBI Gene

488

PubChem

488

Alliance of Genome Resources

HGNC:812

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Calcium transport
Disease variant
Disulfide bond
Endoplasmic reticulum
Epilepsy
Magnesium
Metal-binding
Nitration
Phosphoprotein
Reference proteome
Sarcoplasmic reticulum
Translocase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0S2Z3L2	Calcium pump 2 Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform Endoplasmic reticulum class 1/2 Ca(2+) ATPase
P16615	Calcium pump 2 Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform Endoplasmic reticulum class 1/2 Ca(2+) ATPase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 41 in total

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GO Term	Evidence Code	PMID
autophagosome assembly	IDA	28890335
autophagosome assembly	IBA
regulation of the force of heart contraction	IEA
intracellular calcium ion homeostasis	IDA	10587333
intracellular calcium ion homeostasis	IMP	18068335

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

signal transduction [inference]

ER-nucleus signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling

membrane docking [inference]

organelle localization by membrane tethering

cellular localization [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

calcium ion import into sarcoplasmic reticulum

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

membrane organization [inference]

T-tubule organization

mitochondrion-endoplasmic reticulum membrane tethering

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle hypertrophy [inference]

muscle hypertrophy in response to stress [inference]

cardiac muscle hypertrophy in response to stress

striated muscle hypertrophy [inference]

cardiac muscle hypertrophy [inference]

cardiac muscle hypertrophy in response to stress

muscle adaptation [inference]

muscle hypertrophy in response to stress [inference]

cardiac muscle hypertrophy in response to stress

striated muscle adaptation [inference]

cardiac muscle adaptation [inference]

cardiac muscle hypertrophy in response to stress

relaxation of muscle [inference]

relaxation of cardiac muscle

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

positive regulation of endoplasmic reticulum calcium ion concentration

neuron cellular homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

positive regulation of endoplasmic reticulum calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

positive regulation of endoplasmic reticulum calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

positive regulation of endoplasmic reticulum calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

positive regulation of endoplasmic reticulum calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

positive regulation of endoplasmic reticulum calcium ion concentration

response to stimulus [inference]

response to stress [inference]

muscle hypertrophy in response to stress [inference]

cardiac muscle hypertrophy in response to stress

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

muscle adaptation [inference]

muscle hypertrophy in response to stress [inference]

cardiac muscle hypertrophy in response to stress

striated muscle adaptation [inference]

cardiac muscle adaptation [inference]

cardiac muscle hypertrophy in response to stress

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

sarcoplasmic reticulum calcium ion transport

calcium ion import into sarcoplasmic reticulum

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

intracellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

calcium ion import into sarcoplasmic reticulum

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

organic substance transport [inference]

calcium ion transport [inference]

sarcoplasmic reticulum calcium ion transport

calcium ion import into sarcoplasmic reticulum

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

establishment of localization in cell [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

calcium ion import into sarcoplasmic reticulum

organelle localization [inference]

organelle localization by membrane tethering

cellular localization [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

calcium ion import into sarcoplasmic reticulum

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of multicellular organismal process [inference]

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of blood circulation [inference]

negative regulation of heart contraction

regulation of response to stimulus [inference]

regulation of muscle adaptation [inference]

regulation of skeletal muscle adaptation [inference]

transition between fast and slow fiber

regulation of cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of striated muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of cardiac muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of muscle adaptation [inference]

regulation of skeletal muscle adaptation [inference]

transition between fast and slow fiber

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of the force of heart contraction

regulation of heart rate [inference]

positive regulation of heart rate

negative regulation of heart contraction

positive regulation of heart contraction [inference]

positive regulation of heart rate

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of cardiac conduction

negative regulation of blood circulation [inference]

negative regulation of heart contraction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of multicellular organismal process [inference]

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

negative regulation of multicellular organismal process [inference]

negative regulation of blood circulation [inference]

negative regulation of heart contraction

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of cardiac muscle cell action potential involved in regulation of contraction

regulation of biological quality [inference]

regulation of the force of heart contraction

regulation of heart rate [inference]

positive regulation of heart rate

regulation of membrane potential [inference]

regulation of cardiac muscle cell membrane potential

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of cardiac muscle cell action potential involved in regulation of contraction

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of binding [inference]

negative regulation of protein binding [inference]

negative regulation of receptor binding

regulation of binding [inference]

regulation of protein binding [inference]

negative regulation of protein binding [inference]

negative regulation of receptor binding

regulation of receptor binding [inference]

negative regulation of receptor binding

negative regulation of binding [inference]

negative regulation of protein binding [inference]

negative regulation of receptor binding

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
longitudinal sarcoplasmic reticulum	IDA	16402920
membrane	IDA	22375059
membrane	IBA
sarcoplasmic reticulum	IDA	12804600 16402920
platelet dense tubular network membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

calcium ion-transporting ATPase complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

calcium ion-transporting ATPase complex

cellular anatomical entity [inference]

longitudinal sarcoplasmic reticulum

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

sarcoplasmic reticulum membrane

bounding membrane of organelle [inference]

cell junction [inference]

synapse [inference]

ribbon synapse

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

sarcoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

sarcoplasmic reticulum

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential	IDA	28890335
P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential	IBA
lncRNA binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

lncRNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATPase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
P-type calcium transporter activity
calcium ion transmembrane transport
calcium ion transport
intracellular calcium ion homeostasis
monoatomic ion transport
nucleotide binding

Displaying **all 10** entries
InterPro
Cation-transporting P-type ATPase, C-terminal
Cation-transporting P-type ATPase, N-terminal
HAD superfamily
HAD-like superfamily
P-type ATPase, A domain superfamily
P-type ATPase, cytoplasmic domain N
P-type ATPase, haloacid dehalogenase domain
P-type ATPase, phosphorylation site
P-type ATPase, transmembrane domain superfamily
P-type ATPase

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050606	acrokeratosis verruciformis	Alliance of Genome Resources
DOID:10825	essential hypertension	Alliance of Genome Resources
DOID:2734	keratosis follicularis	Alliance of Genome Resources
DOID:6432	pulmonary hypertension	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of 84 in total

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Species	Gene ID	Orthologous MAtrix
Nannospalax galili	103739078	NANGA08022
Serinus canaria	103818170	SERCA13093
Rhinopithecus roxellana	104674813	RHIRO08604
Pteropus vampyrus	105289209	PTEVA13624
Macaca nemestrina	105493427	MACNE05765
Mandrillus leucophaeus	105552249	MANLE11210
Cercocebus atys	105573204	CERAT12137
Aotus nancymaae	105728628	AOTNA01763
Propithecus coquereli	105825610	PROCO07089
Salmo salar	106563153	SALSA14350

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Acknowledgements