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NRAS proto-oncogene, GTPase

Summary

Gene Symbol

NRAS

Aliases

N-ras

Organism

Homo sapiens (human)

External Links

NCBI Gene

4893

HGNC

7989

PubChem

4893

Alliance of Genome Resources

HGNC:7989

Annotation

Keyword

3D-structure
Acetylation
Cell membrane
Disease variant
GTP-binding
Glycoprotein
Golgi apparatus
Hydrolase
Isopeptide bond
Methylation
Palmitate
Phosphoprotein
Prenylation
Proto-oncogene
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q5U091	Transforming protein N-Ras
P01111	Transforming protein N-Ras

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
MAPK cascade	TAS
positive regulation of endothelial cell proliferation	IMP	23619365
Ras protein signal transduction	IDA	30712867
Ras protein signal transduction	IBA
myoblast differentiation	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

cellular developmental process [inference]

cell differentiation [inference]

myoblast differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myoblast differentiation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
endoplasmic reticulum membrane	TAS
Golgi apparatus	IDA	21968647
cytosol	TAS
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

tertiary granule membrane

bounding membrane of organelle [inference]

Golgi membrane

secretory granule membrane [inference]

tertiary granule membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
GTPase activity	TAS
GTPase activity	IDA	30712867
GTPase activity	IBA
G protein activity	IEA
protein binding	IPI	18641128 20080631 21478863 28514442 30194290 31980649 32296183 32707033 32814053 33961781 34591642

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

G protein activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

GDP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

molecular function regulator activity [inference]

G protein activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ras

Functional Category

J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
GDP binding
GTP binding
Ras protein signal transduction

Displaying **all 4** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Small GTP-binding protein domain
Small GTPase, Ras-type
Small GTPase

Human Protein Atlas

ENSG00000213281

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:19669

H₂O + GTP

H⁺ + phosphate + GDP

Enzyme

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 14 in total

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DO ID	Disease Name	Source
DOID:0050908	myelodysplastic syndrome	Alliance of Genome Resources
DOID:0060584	Noonan syndrome 6	Alliance of Genome Resources
DOID:0110117	autoimmune lymphoproliferative syndrome type 4	Alliance of Genome Resources
DOID:0111162	epidermal nevus	Alliance of Genome Resources
DOID:0111359	large congenital melanocytic nevus	Alliance of Genome Resources
DOID:0111530	linear nevus sebaceous syndrome	Alliance of Genome Resources
DOID:1909	melanoma	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources
DOID:3969	papillary thyroid carcinoma	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000028	Cryptorchidism
HP:0000044	Hypogonadotropic hypogonadism
HP:0000078	Abnormality of the genital system
HP:0000085	Horseshoe kidney
HP:0000179	Thick lower lip vermilion
HP:0000194	Open mouth
HP:0000218	High palate
HP:0000232	Everted lower lip vermilion
HP:0000238	Hydrocephalus

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Disease ID	Disease Name
OMIM:249400	neurocutaneous melanocytosis
OMIM:163200	linear nevus sebaceous syndrome
OMIM:137550	large congenital melanocytic nevus
OMIM:613224	Noonan syndrome 6
OMIM:614470	autoimmune lymphoproliferative syndrome type 4
OMIM:188470	thyroid cancer, nonmedullary, 2
ORPHA:648	Noonan syndrome
OMIM:162900	nevus, epidermal
ORPHA:626	large congenital melanocytic nevus
OMIM:114500	colorectal cancer

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3265	FB:FBgn0003205
Drosophila melanogaster	3845	FB:FBgn0003205
Xenopus tropicalis	4893	Xenbase:XB-GENE-6085898
Drosophila melanogaster	16653	FB:FBgn0003205
Mus musculus	18176		MOUSE38164
Rattus norvegicus	24605		RATNO24621
Canis lupus familiaris	403872		CANLF05274
Bos taurus	506322		BOVIN26201
Monodelphis domestica	554197		MONDO15129
Macaca mulatta	709089		MACMU24546

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UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements