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NRAS proto-oncogene, GTPase

Summary

Gene Symbol

NRAS

Aliases

N-ras

Organism

Homo sapiens (human)

External Links

NCBI Gene

4893

HGNC

7989

PubChem

4893

Alliance of Genome Resources

HGNC:7989

Annotation

Keyword

3D-structure
Acetylation
Cell membrane
Disease variant
GTP-binding
Glycoprotein
Golgi apparatus
Hydrolase
Isopeptide bond
Methylation
Palmitate
Phosphoprotein
Prenylation
Proto-oncogene
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q5U091	Transforming protein N-Ras
P01111	Transforming protein N-Ras

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
MAPK cascade	TAS
positive regulation of endothelial cell proliferation	IMP	23619365
Ras protein signal transduction	IDA	30712867
Ras protein signal transduction	IBA
myoblast differentiation	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

cellular developmental process [inference]

cell differentiation [inference]

myoblast differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myoblast differentiation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
endoplasmic reticulum membrane	TAS
Golgi apparatus	IDA	21968647
cytosol	TAS
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

tertiary granule membrane

bounding membrane of organelle [inference]

Golgi membrane

secretory granule membrane [inference]

tertiary granule membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
GTPase activity	TAS
GTPase activity	IDA	30712867
GTPase activity	IBA
G protein activity	IEA
protein binding	IPI	18641128 20080631 21478863 28514442 30194290 31980649 32296183 32707033 32814053 33961781 34591642

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

G protein activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

GDP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

molecular function regulator activity [inference]

G protein activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GTP-binding protein

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
GDP binding
GTP binding
Ras protein signal transduction
nucleotide binding

Displaying **all 4** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Small GTP-binding protein domain
Small GTPase, Ras-type
Small GTPase

Human Protein Atlas

ENSG00000213281

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:19669

H₂O + GTP

H⁺ + phosphate + GDP

Enzyme

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 14 in total

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DO ID	Disease Name	Source
DOID:0050908	myelodysplastic syndrome	Alliance of Genome Resources
DOID:0060584	Noonan syndrome 6	Alliance of Genome Resources
DOID:0110117	autoimmune lymphoproliferative syndrome type 4	Alliance of Genome Resources
DOID:0111162	epidermal nevus	Alliance of Genome Resources
DOID:0111359	large congenital melanocytic nevus	Alliance of Genome Resources
DOID:0111530	linear nevus sebaceous syndrome	Alliance of Genome Resources
DOID:1909	melanoma	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources
DOID:3969	papillary thyroid carcinoma	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **31 - 40** of **209** in total

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HPO ID	HPO Term
HP:0000463	Anteverted nares
HP:0000465	Webbed neck
HP:0000470	Short neck
HP:0000474	Thickened nuchal skin fold
HP:0000476	Cystic hygroma
HP:0000478	Abnormality of the eye
HP:0000486	Strabismus
HP:0000494	Downslanted palpebral fissures
HP:0000504	Abnormality of vision
HP:0000506	Telecanthus

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Disease ID	Disease Name
OMIM:613224	Noonan syndrome 6
OMIM:114500	colorectal cancer
ORPHA:648	Noonan syndrome
OMIM:249400	neurocutaneous melanocytosis
ORPHA:2612	linear nevus sebaceous syndrome
OMIM:188470	thyroid cancer, nonmedullary, 2
OMIM:162900	nevus, epidermal
OMIM:137550	large congenital melanocytic nevus
OMIM:163200	linear nevus sebaceous syndrome
OMIM:614470	autoimmune lymphoproliferative syndrome type 4

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Orthologous MAtrix
Phascolarctos cinereus	110219182	PHACI21083
Vulpes vulpes	112916766	VULVU09509
Pseudonaja textilis	113444286	PSETE17027
Bos indicus x Bos taurus	113889190	BOBOX08392
Vombatus ursinus	114046417	VOMUR25779
Podarcis muralis	114599398	PODMU04195
Strigops habroptila	115602282	STRHB05586
Rhinolophus ferrumequinum	117014672	RHIFE25754
Balaenoptera musculus	118893681	BALMU23643
Panthera leo	122228482	PANLE11267

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements