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toll like receptor 4

Summary

Gene Symbol

TLR4

Organism

Felis catus (domestic cat)

External Links

NCBI Gene: 493698
PubChem: 493698

Annotation

Keyword

Cell membrane
Cell projection
Disulfide bond
Endosome
Glycoprotein
Inflammatory response
Innate immunity
Leucine-rich repeat
NAD
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P58727

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
toll-like receptor signaling pathway	IEA	22301074 30032202
MyD88-dependent toll-like receptor signaling pathway
inflammatory response	IEA	30032202
immune response	IEA	22301074 30032202
detection of lipopolysaccharide

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

immune response

innate immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

innate immune response

immune response

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

innate immune response

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to biotic stimulus [inference]

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

innate immune response

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 beta production [inference]

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 beta production [inference]

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 beta production [inference]

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

cell surface pattern recognition receptor signaling pathway [inference]

cell surface toll-like receptor signaling pathway [inference]

toll-like receptor 4 signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 beta production [inference]

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

regulation of NLRP3 inflammasome complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

regulation of NLRP3 inflammasome complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 beta production [inference]

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 beta production

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ruffle
early endosome
plasma membrane
membrane	IEA	22301074 30032202
lipopolysaccharide receptor complex

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

lipopolysaccharide receptor complex

membrane protein complex [inference]

lipopolysaccharide receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

ruffle

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
lipopolysaccharide binding	IEA	30032202
lipopolysaccharide immune receptor activity	IEA	30032202
transmembrane signaling receptor activity	IEA	22301074 30032202
protein binding	IEA	22301074
NAD+ nucleotidase, cyclic ADP-ribose generating

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

NAD+ nucleosidase activity [inference]

NAD+ nucleotidase, cyclic ADP-ribose generating

binding [inference]

protein binding

lipid binding [inference]

lipopolysaccharide binding

carbohydrate derivative binding [inference]

lipopolysaccharide binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

pattern recognition receptor activity [inference]

lipopolysaccharide immune receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

toll

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
immune response
toll-like receptor signaling pathway

Displaying **all 5** entries
InterPro
Leucine-rich repeat domain superfamily
Leucine-rich repeat
Toll-like receptor
Toll/interleukin-1 receptor homology (TIR) domain superfamily
Toll/interleukin-1 receptor homology (TIR) domain

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	7099	HUMAN98195
Mus musculus	21898	MOUSE40157
Rattus norvegicus	29260	RATNO33665
Bos taurus	281536	BOVIN35208
Sus scrofa	399541	PIGXX16037
Danio rerio	403131	DANRE05736
Danio rerio	403132	DANRE05762
Canis lupus familiaris	403417	CANLF02482
Ovis aries	554263	SHEEP08670
Macaca mulatta	574360	MACMU13260

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements