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Toll-like receptor 4

Summary

UniProt ID

P58727

Gene Symbol

TLR4

Organism

Felis catus (domestic cat)

External Links

PubChem: P58727

Annotation

Keyword

Cell membrane
Cell projection
Disulfide bond
Endosome
Glycoprotein
Inflammatory response
Innate immunity
Leucine-rich repeat
NAD
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
inflammatory response
macrophage activation
innate immune response
positive regulation of interleukin-1 beta production
MyD88-dependent toll-like receptor signaling pathway
defense response to Gram-negative bacterium
detection of lipopolysaccharide
toll-like receptor 4 signaling pathway
positive regulation of NLRP3 inflammasome complex assembly

Displaying **all 4** entries
GO Term
plasma membrane
lipopolysaccharide receptor complex
ruffle
early endosome

Displaying **all 4** entries
GO Term
transmembrane signaling receptor activity
NAD+ nucleotidase, cyclic ADP-ribose generating
lipopolysaccharide binding
lipopolysaccharide immune receptor activity

Annotation information from UniProt.

Sequence

MMPPTRLAGTLIPAMAFLSCLRPESWDPCVEVVPNITYQCMDLNLHKIPDNIPSSTKDLDMSFNPLRNLGSHSFSNFPELQVLDLSRCEIQIIEDDAYQGLNHLSILILTGNPIQRLFPGAFSGLSSLQTLVAVETNIASLEDFPIGHLKTLKELNVAHNLIHSFKLPEYFSNMSNLEYLDLSNNKIQNIYHKDLQVLHQKPLLNLSLDLSLNPLDFIQPGAFKEVKLRELTLRSNFNSTDVMKASIQGLAGLQIHQLVLGEFKNERNLGRFDKSILEGLCNLIIEKFRIAYFDKFSEDAIDSFNCLANVSTISLVHLYFKGLKQLPKNLGWQRLELVNCEFEQFPTWKLDPLKELVFSANEVRNAFTQVKLESLEFLDLSRNDFSLKSCCSERDLGTTRLKHLDLSFNNIITISSNFLGLEQLEYLDFQHSSLKQVSDFSVFLPLKNLRYLDISYTHTQVAFHGIFNGLISLQILKMAGNSFQDNFLPNIFMELTNLTILDLSDCQLEQVSQVAFNSLPKLQLLNMSHNHLLSLDTLPYEPLHSLQTLDCSFNRIVASKEQELRHFPSNLSSLNLTRNDFACVCEHQSFLQWVKDQRQLLVEVEQMVCAKPLDMQGMPMLNFRNATCQVRKTIITGSVFTVLLVFLVVVLVYKFYFHLMLLAGCKKYSRGESTYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYGIAQTWQFLSSRAGIIFIVLQKLEKSLLRQQVELYRLLNRNTYLEWEDSVLGRHIFWRRLRKALLDGKPRCPEGMADAEGS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	Source
35	N-linked (GlcNAc...) asparagine	UniProt
173	N-linked (GlcNAc...) asparagine	UniProt
205	N-linked (GlcNAc...) asparagine	UniProt
238	N-linked (GlcNAc...) asparagine	UniProt
309	N-linked (GlcNAc...) asparagine	UniProt
497	N-linked (GlcNAc...) asparagine	UniProt
526	N-linked (GlcNAc...) asparagine	UniProt
570	N-linked (GlcNAc...) asparagine	UniProt
575	N-linked (GlcNAc...) asparagine	UniProt
625	N-linked (GlcNAc...) asparagine	UniProt