GlyCosmos Portal

Annotation

Keyword

Glycoprotein
Immunity
Melanin biosynthesis
Reference proteome
Secreted
Serine protease inhibitor
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VFC2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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2

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GO Term	Evidence Code	PMID
imaginal disc-derived wing expansion	IMP	18956323
melanin biosynthetic process
negative regulation of proteolysis	IMP ISM	19581577 19849829
negative regulation of Toll receptor ligand protein activation cascade	IMP	19581577
immune system process

GO Hierarchy

biological process

immune system process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

secondary metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process

pigment metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

pigment biosynthetic process [inference]

melanin biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

growth [inference]

developmental growth [inference]

developmental growth involved in morphogenesis [inference]

imaginal disc-derived wing expansion

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	HDA	15466469
extracellular space	IBA IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying 1 entry
GO Term	Evidence Code	PMID
serine-type endopeptidase inhibitor activity	IEA

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serpin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
serine-type endopeptidase inhibitor activity

Displaying **all 6** entries
InterPro
Serpin domain
Serpin family
Serpin superfamily, domain 1
Serpin superfamily, domain 2
Serpin superfamily
Serpin, conserved site

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
membrane	FB:FBrf0231198
extracellular region	PMID:15466469
cytoplasm	FB:FBrf0219073

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:0050831	familial encephalopathy with neuroserpin inclusion bodies	Alliance of Genome Resources
DOID:0060903	thrombosis	Alliance of Genome Resources
DOID:10159	osteonecrosis	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:11247	disseminated intravascular coagulation	Alliance of Genome Resources
DOID:1168	familial hyperlipidemia	Alliance of Genome Resources
DOID:1184	nephrotic syndrome	Alliance of Genome Resources
DOID:14115	toxic shock syndrome	Alliance of Genome Resources
DOID:2394	ovarian cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	462	HGNC:775
Homo sapiens	1992	HGNC:3311
Homo sapiens	5270	HGNC:8951
Homo sapiens	5274	HGNC:8943
Homo sapiens	5276	HGNC:8945
Mus musculus	11905	MGI:88095
Mus musculus	20713	MGI:1194506
Rattus norvegicus	29366	RGD:3748
Mus musculus	66222	MGI:1913472
Rattus norvegicus	116459	RGD:619896

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements