GlyCosmos Portal

Submissions

Serpin 88Ea

Summary

Gene Symbol

Spn88Ea

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

49804

PubChem

49804

Alliance of Genome Resources

FB:FBgn0028984

Annotation

Keyword

Glycoprotein
Immunity
Melanin biosynthesis
Reference proteome
Secreted
Serine protease inhibitor
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VFC2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
immune system process
negative regulation of peptidase activity
melanin biosynthetic process
negative regulation of innate immune response	IMP	19581577
negative regulation of proteolysis	ISM	19849829

GO Hierarchy

biological process

immune system process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

secondary metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process

pigment metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

pigment biosynthetic process [inference]

melanin biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

growth [inference]

developmental growth [inference]

developmental growth involved in morphogenesis [inference]

imaginal disc-derived wing expansion

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	HDA	15466469
extracellular space	IBA
extracellular space	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying 1 entry
GO Term	Evidence Code	PMID
serine-type endopeptidase inhibitor activity	IEA

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serpin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
serine-type endopeptidase inhibitor activity

Displaying **all 6** entries
InterPro
Serpin domain
Serpin family
Serpin superfamily, domain 1
Serpin superfamily, domain 2
Serpin superfamily
Serpin, conserved site

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
membrane	FB:FBrf0231198
cytoplasm	FB:FBrf0219073
extracellular region	PMID:15466469

Ortholog

Displaying entries **1 - 10** of 48 in total

1

2

3

4

5

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	12	WB:WBGene00005649
Homo sapiens	462	HGNC:775
Homo sapiens	1992	HGNC:3311
Danio rerio	3053	ZFIN:ZDB-GENE-030711-2
Caenorhabditis elegans	5054	WB:WBGene00005649
Caenorhabditis elegans	5055	WB:WBGene00005649
Caenorhabditis elegans	5104	WB:WBGene00005649
Caenorhabditis elegans	5265	WB:WBGene00005649
Caenorhabditis elegans	5268	WB:WBGene00005649
Caenorhabditis elegans	5269	WB:WBGene00005649

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements