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Serine protease inhibitor 88Ea

Summary

UniProt ID: Q9VFC2
Gene Symbol: Spn88Ea CG18525 Spn5
Gene ID: 49804
Organism: Drosophila melanogaster (fruit fly)

External Links

Re-Glyco: Q9VFC2

Annotation

Keyword: Glycoprotein Immunity Melanin biosynthesis Reference proteome Secreted Serine protease inhibitor Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
immune system process
melanin biosynthetic process
negative regulation of innate immune response	IMP	PMID
negative regulation of proteolysis	ISM	PMID
negative regulation of proteolysis	IMP	PMID

GO Hierarchy

biological process

immune system process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

secondary metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process

pigment metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

pigment biosynthetic process [inference]

melanin biosynthetic process

growth [inference]

developmental growth [inference]

developmental growth involved in morphogenesis [inference]

imaginal disc-derived wing expansion

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

Displaying **all 4** entries
GO Term	Evidence Code	Reference
extracellular region	EXP	PMID
extracellular region	IEA	GO_REF
extracellular region	HDA	PMID
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

Displaying 1 entry
GO Term	Evidence Code	Reference
serine-type endopeptidase inhibitor activity	IEA	GO_REF

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MHILSISLMAVLPAIALAGLCGVEPDAGLLDQRLNLYKGQQNFAVSMLNVIRQSTPNENVFFSPYSTYHALLLAYFGSSGDTEKELAKVLHLDWADSKEVVRSAYILEKMNRKERQSKMPLEFSSADRIFFANDLHVTECARNRLAEEVQQIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADEITPRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQQKGTFLLNVDEQLRAHVLQLPYRTVFESQEKEDSSPDENSDISMVLILPPFNSNSLEDVLSRLNADSLDDSLKQAMPREIEVSLPKFEFEQRLELNPILAKMGVSKMFDESVATFDDLTSETISIGDSKHVAKIKVDEEGSTAAAATVLFTYRSARPVEPAKFECNHPFLFVIYDRTSRSILFTGIYRDPKTIKQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
224	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
CASP4 inflammasome assembly	Drosophila melanogaster
Collagen biosynthesis and modifying enzymes	Drosophila melanogaster
Neutrophil degranulation	Drosophila melanogaster
Platelet degranulation	Drosophila melanogaster
Post-translational protein phosphorylation	Drosophila melanogaster
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Drosophila melanogaster
Regulation of FXIIa and plasma kallikrein activity	Drosophila melanogaster
Regulation of IGF Activity by IGFBP	Drosophila melanogaster

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