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proprotein convertase subtilisin/kexin type 5

Summary

Gene Symbol

PCSK5

Organism

Homo sapiens (human)

External Links

NCBI Gene

5125

PubChem

5125

Alliance of Genome Resources

HGNC:8747

Annotation

Keyword

Alternative splicing
Cleavage on pair of basic residues
Glycoprotein
Pregnancy
Reference proteome
Repeat
Secreted
Serine protease
Signal
Transmembrane helix
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92824	Proprotein convertase 5 Proprotein convertase 6 Subtilisin/kexin-like protease PC5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
kidney development	ISS	8940009
kidney development	IMP	18519639
renin secretion into blood stream	IEP	8901832
signal peptide processing	IDA	16912035
cell-cell signaling	TAS	8901832

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

amide metabolic process [inference]

peptide metabolic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

protein maturation [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

hormone metabolic process [inference]

peptide hormone processing

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

protein maturation [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

protein maturation [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

protein maturation [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

cellular process [inference]

cell communication [inference]

cell-cell signaling

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

renin secretion into blood stream

viral process [inference]

viral life cycle

reproductive process [inference]

embryo implantation

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

appendage morphogenesis [inference]

limb morphogenesis

anatomical structure development [inference]

tube development [inference]

respiratory tube development

digestive tract development [inference]

embryonic digestive tract development

animal organ development [inference]

embryonic organ development [inference]

embryonic digestive tract development

system development [inference]

skeletal system development [inference]

embryonic skeletal system development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

renin secretion into blood stream

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

renin secretion into blood stream

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IBA
extracellular region	TAS
extracellular space	ISS	8940009
Golgi apparatus	TAS	8947550
Golgi apparatus	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	EXP	16109723 20581395
serine-type endopeptidase activity	IDA	8901832
serine-type endopeptidase activity	IBA
protein binding	IPI	25416956 32296183
peptidase activity	IDA	15606899

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

amide binding [inference]

peptide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

proprotein convertase subtilisin/kexin type 5

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 3** entries
InterPro
EGF-like domain
Furin-like repeat
Growth factor receptor cysteine-rich domain superfamily

Ortholog

Displaying entries **41 - 50** of 55 in total

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Species	Gene ID	Orthologous MAtrix
Callorhinchus milii	103182388	CALMI24918
Chlorocebus sabaeus	103219608	CHLSB03437
Carlito syrichta	103276920	CARSF00315
Salmo salar	106585692	SALSA89325
Sinocyclocheilus grahami	107548272	SINGR60519
Cyprinus carpio carpio	109053363	CYPCA75070
Crocodylus porosus	109323408	CROPO12754
Athene cunicularia	113490110	ATHCN12414
Bos indicus x Bos taurus	113897130	BOBOX32021
Salmo trutta	115164824	SALTR59147